THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT
Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1α) in patients with Benign Prostate Hyperplas...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IKATAN AHLI UROLOGI INDONESIA
2017-07-01
|
| Series: | Jurnal Urologi Indonesia |
| Subjects: | |
| Online Access: | http://juri.urologi.or.id/juri/article/view/306 |
| _version_ | 1818948176209510400 |
|---|---|
| author | Andry Irawan Ignatius Riwanto Eriawan Agung Nugroho |
| author_facet | Andry Irawan Ignatius Riwanto Eriawan Agung Nugroho |
| author_sort | Andry Irawan |
| collection | DOAJ |
| description | Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1α) in patients with Benign Prostate Hyperplasia (BPH) were performed Trans urethral resection of the prostate (TURP) surgery. Material & method: Experimental study with the draft "randomized control trial". Comparing angiogenesis changes between groups of BPH patients who underwent TURP surgery to assess the expression of HIF-1α and Δ Ht (Hematocrit) after administration of dutasteride, green tea with combination of dutasteride and green tea for 14 days. Results: The combination of dutasteride and green tea was not significant in reducing the expression of HIF-1α. Mean P1 group (59.32 ± 14.69); P2 group (59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal test results obtained p=0.491 walis which means the difference percentage of HIF-1α among the 4 groups was not significant. The mean Δ Ht P1 group (0.61 ± 0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ± 0.275). In statistical test with Mann Whitney test comparing the percentage reduction obtained Ht levels dutasteride group against group of green tea obtained p=0.213 means that there is no significant difference. Where a significant difference to the other groups. Conclusion: The combination of dutasteride and green tea for 14 days before TURP surgery does not reduce the expression of HIF-1α in BPH patients who underwent TURP surgery. Δ Ht significant decline in the combination group compared with other groups and might be influenced by several factors during TURP surgery. |
| first_indexed | 2024-12-20T08:42:38Z |
| format | Article |
| id | doaj.art-090cedfb2b964de7be12aad02c6f1991 |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-12-20T08:42:38Z |
| publishDate | 2017-07-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-090cedfb2b964de7be12aad02c6f19912022-12-21T19:46:20ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022017-07-0124210.32421/juri.v24i2.306306THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRITAndry Irawan0Ignatius Riwanto1Eriawan Agung Nugroho2Department of Surgery, Faculty of Medicine/Diponegoro University, Kariadi General Hospital, Semarang.Division of Digestive/Department of Surgery, Faculty of Medicine/Diponegoro University, Kariadi General Hospital, Semarang.Division of Urology/Department of Surgery, Faculty of Medicine/Diponegoro University, Kariadi General Hospital, Semarang.Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1α) in patients with Benign Prostate Hyperplasia (BPH) were performed Trans urethral resection of the prostate (TURP) surgery. Material & method: Experimental study with the draft "randomized control trial". Comparing angiogenesis changes between groups of BPH patients who underwent TURP surgery to assess the expression of HIF-1α and Δ Ht (Hematocrit) after administration of dutasteride, green tea with combination of dutasteride and green tea for 14 days. Results: The combination of dutasteride and green tea was not significant in reducing the expression of HIF-1α. Mean P1 group (59.32 ± 14.69); P2 group (59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal test results obtained p=0.491 walis which means the difference percentage of HIF-1α among the 4 groups was not significant. The mean Δ Ht P1 group (0.61 ± 0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ± 0.275). In statistical test with Mann Whitney test comparing the percentage reduction obtained Ht levels dutasteride group against group of green tea obtained p=0.213 means that there is no significant difference. Where a significant difference to the other groups. Conclusion: The combination of dutasteride and green tea for 14 days before TURP surgery does not reduce the expression of HIF-1α in BPH patients who underwent TURP surgery. Δ Ht significant decline in the combination group compared with other groups and might be influenced by several factors during TURP surgery.http://juri.urologi.or.id/juri/article/view/306HIF-1αhematocritbenign prostate hyperplasiadutasteridegreen tea |
| spellingShingle | Andry Irawan Ignatius Riwanto Eriawan Agung Nugroho THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT Jurnal Urologi Indonesia HIF-1α hematocrit benign prostate hyperplasia dutasteride green tea |
| title | THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT |
| title_full | THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT |
| title_fullStr | THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT |
| title_full_unstemmed | THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT |
| title_short | THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT |
| title_sort | efficacy of dutasteride and green tea towards bleeding on bph after turp study their effect on hif 1α expression hematocrit |
| topic | HIF-1α hematocrit benign prostate hyperplasia dutasteride green tea |
| url | http://juri.urologi.or.id/juri/article/view/306 |
| work_keys_str_mv | AT andryirawan theefficacyofdutasterideandgreenteatowardsbleedingonbphafterturpstudytheireffectonhif1aexpressionhematocrit AT ignatiusriwanto theefficacyofdutasterideandgreenteatowardsbleedingonbphafterturpstudytheireffectonhif1aexpressionhematocrit AT eriawanagungnugroho theefficacyofdutasterideandgreenteatowardsbleedingonbphafterturpstudytheireffectonhif1aexpressionhematocrit AT andryirawan efficacyofdutasterideandgreenteatowardsbleedingonbphafterturpstudytheireffectonhif1aexpressionhematocrit AT ignatiusriwanto efficacyofdutasterideandgreenteatowardsbleedingonbphafterturpstudytheireffectonhif1aexpressionhematocrit AT eriawanagungnugroho efficacyofdutasterideandgreenteatowardsbleedingonbphafterturpstudytheireffectonhif1aexpressionhematocrit |