Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes. Yet, how it does so remains poorly understood as we lack tools to di...

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Bibliographic Details
Main Authors: Pooja Suresh, Alexandra F Long, Sophie Dumont
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
mammalian
spindle
kinetochore-fiber
mechanics
dynamics
microneedle
Online Access:https://elifesciences.org/articles/53807

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