Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell
Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as thei...
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| Format: | Article |
| Language: | English |
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Jenderal Soedirman University
2022-11-01
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| Series: | Molekul |
| Online Access: | http://jos.unsoed.ac.id/index.php/jm/article/view/6425 |
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| author | Unang Supratman Samuel San Parulian Nurlelasari Nurlelasari Al Arofatus Naini Tri Mayanti Erina Hilmayanti Desi Harneti Darwati Darwati Rani Maharani Kindi Farabi Risyandi Anwar Sofa Fajriah Muhamad Nurul Azmi Yoshihito Shiono |
| author_facet | Unang Supratman Samuel San Parulian Nurlelasari Nurlelasari Al Arofatus Naini Tri Mayanti Erina Hilmayanti Desi Harneti Darwati Darwati Rani Maharani Kindi Farabi Risyandi Anwar Sofa Fajriah Muhamad Nurul Azmi Yoshihito Shiono |
| author_sort | Unang Supratman |
| collection | DOAJ |
| description | Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM. |
| first_indexed | 2024-04-12T06:36:32Z |
| format | Article |
| id | doaj.art-09114e6cc63742aeb4bea52acb173e1a |
| institution | Directory Open Access Journal |
| issn | 1907-9761 2503-0310 |
| language | English |
| last_indexed | 2024-04-12T06:36:32Z |
| publishDate | 2022-11-01 |
| publisher | Jenderal Soedirman University |
| record_format | Article |
| series | Molekul |
| spelling | doaj.art-09114e6cc63742aeb4bea52acb173e1a2022-12-22T03:43:51ZengJenderal Soedirman UniversityMolekul1907-97612503-03102022-11-0117341342010.20884/1.jm.2022.17.3.64256425Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer CellUnang Supratman0Samuel San Parulian1Nurlelasari Nurlelasari2Al Arofatus Naini3Tri Mayanti4Erina Hilmayanti5Desi Harneti6Darwati Darwati7Rani Maharani8Kindi Farabi9Risyandi Anwar10Sofa Fajriah11Muhamad Nurul Azmi12Yoshihito Shiono13Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, JatinangorHerbal Medicine Research, Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, SemarangResearch Centre for Raw Materials for Medicine and Traditional Medicine, National Research and Innovation Agency (BRIN), Tangerang Selatan, BantenSchool of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden,PenangDepartment of Food, Life, and Environmental Science, Faculty of Agriculture,Yamagata University, Tsuruoka, YamagataSesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.http://jos.unsoed.ac.id/index.php/jm/article/view/6425 |
| spellingShingle | Unang Supratman Samuel San Parulian Nurlelasari Nurlelasari Al Arofatus Naini Tri Mayanti Erina Hilmayanti Desi Harneti Darwati Darwati Rani Maharani Kindi Farabi Risyandi Anwar Sofa Fajriah Muhamad Nurul Azmi Yoshihito Shiono Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Molekul |
| title | Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell |
| title_full | Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell |
| title_fullStr | Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell |
| title_full_unstemmed | Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell |
| title_short | Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell |
| title_sort | sesquiterpenoids from stem bark of chisocheton lasiocarpus and their cytotoxic activity against mcf 7 breast cancer cell |
| url | http://jos.unsoed.ac.id/index.php/jm/article/view/6425 |
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