Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter?
Male patients with papillary thyroid carcinoma (PTC) usually have aggressive clinicopathological features, including large tumor size and lymph node metastasis; however, it is unclear whether male sex increases the risk of recurrence. Here, we evaluated the effect of sex on disease-free survival (DF...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/8/1896 |
| _version_ | 1797436520079032320 |
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| author | Hyeji Kim Hyungju Kwon Byung-In Moon |
| author_facet | Hyeji Kim Hyungju Kwon Byung-In Moon |
| author_sort | Hyeji Kim |
| collection | DOAJ |
| description | Male patients with papillary thyroid carcinoma (PTC) usually have aggressive clinicopathological features, including large tumor size and lymph node metastasis; however, it is unclear whether male sex increases the risk of recurrence. Here, we evaluated the effect of sex on disease-free survival (DFS) of patients with PTC. Between 2009 and 2016, 1252 patients who underwent total thyroidectomy for PTC were enrolled; 157 (12.5%) were male and 1095 (87.5%) were female. With a mean follow-up of 6.6 years, five-year DFS rates were comparable between male and female patients (94.9% vs. 96.9%; <i>p</i> = 0.616) after adjusting for potential confounders. Multivariate Cox regression analysis also demonstrated that male sex was not an independent risk factor for recurrence (HR 1.982, 95% CI 0.831–4.726). Subgroup analyses further indicated that both male and female sex—in terms of their associations with five-year DFS—were comparable with other variables, including age < 55 years (94.5% vs. 97.3%; <i>p</i> = 0.520) and tumor size > 1 cm (91.9% vs. 97.0%; <i>p</i> = 0.243). In conclusion, male sex was not associated with the risk of recurrence in patients with PTC. Male patients do not always require aggressive treatment and follow-up approaches. |
| first_indexed | 2024-03-09T11:03:48Z |
| format | Article |
| id | doaj.art-09127d1f54384141865619f767bbeb15 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T11:03:48Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-09127d1f54384141865619f767bbeb152023-12-01T01:05:06ZengMDPI AGCancers2072-66942022-04-01148189610.3390/cancers14081896Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter?Hyeji Kim0Hyungju Kwon1Byung-In Moon2Department of Surgery, Ewha Womans University Medical Center, 1071 Anyangcheon-ro, Yangcheon-Gu, Seoul 07985, KoreaDepartment of Surgery, Ewha Womans University Medical Center, 1071 Anyangcheon-ro, Yangcheon-Gu, Seoul 07985, KoreaDepartment of Surgery, Ewha Womans University Medical Center, 1071 Anyangcheon-ro, Yangcheon-Gu, Seoul 07985, KoreaMale patients with papillary thyroid carcinoma (PTC) usually have aggressive clinicopathological features, including large tumor size and lymph node metastasis; however, it is unclear whether male sex increases the risk of recurrence. Here, we evaluated the effect of sex on disease-free survival (DFS) of patients with PTC. Between 2009 and 2016, 1252 patients who underwent total thyroidectomy for PTC were enrolled; 157 (12.5%) were male and 1095 (87.5%) were female. With a mean follow-up of 6.6 years, five-year DFS rates were comparable between male and female patients (94.9% vs. 96.9%; <i>p</i> = 0.616) after adjusting for potential confounders. Multivariate Cox regression analysis also demonstrated that male sex was not an independent risk factor for recurrence (HR 1.982, 95% CI 0.831–4.726). Subgroup analyses further indicated that both male and female sex—in terms of their associations with five-year DFS—were comparable with other variables, including age < 55 years (94.5% vs. 97.3%; <i>p</i> = 0.520) and tumor size > 1 cm (91.9% vs. 97.0%; <i>p</i> = 0.243). In conclusion, male sex was not associated with the risk of recurrence in patients with PTC. Male patients do not always require aggressive treatment and follow-up approaches.https://www.mdpi.com/2072-6694/14/8/1896papillary thyroid carcinomamalesexrecurrence |
| spellingShingle | Hyeji Kim Hyungju Kwon Byung-In Moon Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter? Cancers papillary thyroid carcinoma male sex recurrence |
| title | Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter? |
| title_full | Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter? |
| title_fullStr | Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter? |
| title_full_unstemmed | Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter? |
| title_short | Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter? |
| title_sort | predictors of recurrence in patients with papillary thyroid carcinoma does male sex matter |
| topic | papillary thyroid carcinoma male sex recurrence |
| url | https://www.mdpi.com/2072-6694/14/8/1896 |
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