Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis
This meta-analysis aimed to assess whether administration tranexamic acid (TXA) could reduce blood loss and vascular events in patients undergoing unicompartmental knee arthroplasty (UKA).We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and case control trial...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958422015123 |
| _version_ | 1797773184158662656 |
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| author | Nengyuan Weng Yawei Gou Fuguo Kuang |
| author_facet | Nengyuan Weng Yawei Gou Fuguo Kuang |
| author_sort | Nengyuan Weng |
| collection | DOAJ |
| description | This meta-analysis aimed to assess whether administration tranexamic acid (TXA) could reduce blood loss and vascular events in patients undergoing unicompartmental knee arthroplasty (UKA).We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and case control trials (CCT) that compared outcomes of patients who did and did not receive TXA during UKA. We searched Cochrane Central Register of including PubMed, EMBASE, Web of Science, the Cochrane Library, Wan Fang data, CBM and CNKI for relevant studies. We assessed the risk of bias of the included studies and calculated pooled risk estimates. The primary outcome was operation time, intraoperative blood loss, postoperative HCT, postoperative HB, transfusion rate, dominant blood loss, postoperative drainage volume, hidden blood loss, total blood loss, postoperative ROM,postoperative VAS score, postoperative complications. Data were using fixed-effects or random-effects models with standard mean differences and risk ratios for continuous and dichotomous variables, respectively.Finally, 9 clinical studies with 744 patients were included in this meta-analysis. Compared with the control group, TXA group could reduced transfusion rate, dominant blood loss, postoperative drainage volume, hidden blood loss, and total blood loss, and increased postoperative HB with statistically significance.The main findings of this meta-analysis are that the transfusion rate, dominant blood loss, postoperative drainage volume, hidden blood loss, total blood loss and postoperative HB in the tranexamic acid group were superior to those in the routine group. Additional high-quality RCTs should be conducted in the future. |
| first_indexed | 2024-03-12T22:02:42Z |
| format | Article |
| id | doaj.art-09128b0f603b4492a170f89918280e18 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-03-12T22:02:42Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-09128b0f603b4492a170f89918280e182023-07-25T04:14:27ZengElsevierAsian Journal of Surgery1015-95842023-08-0146830333045Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysisNengyuan Weng0Yawei Gou1Fuguo Kuang2Department of Orthopedics, People’s Fourth Hospital of Sichuan Province, 1666 Minjiang Road, Jinjiang District, Chengdu, Sichuan, PR ChinaDepartment of Orthopedics, People’s Fourth Hospital of Sichuan Province, 1666 Minjiang Road, Jinjiang District, Chengdu, Sichuan, PR ChinaCorresponding author. Department of Orthopedics, People's Fourth Hospital of Sichuan Province, 1666 Minjiang Road, Jinjiang District, Chengdu, Sichuan, PR China.; Department of Orthopedics, People’s Fourth Hospital of Sichuan Province, 1666 Minjiang Road, Jinjiang District, Chengdu, Sichuan, PR ChinaThis meta-analysis aimed to assess whether administration tranexamic acid (TXA) could reduce blood loss and vascular events in patients undergoing unicompartmental knee arthroplasty (UKA).We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and case control trials (CCT) that compared outcomes of patients who did and did not receive TXA during UKA. We searched Cochrane Central Register of including PubMed, EMBASE, Web of Science, the Cochrane Library, Wan Fang data, CBM and CNKI for relevant studies. We assessed the risk of bias of the included studies and calculated pooled risk estimates. The primary outcome was operation time, intraoperative blood loss, postoperative HCT, postoperative HB, transfusion rate, dominant blood loss, postoperative drainage volume, hidden blood loss, total blood loss, postoperative ROM,postoperative VAS score, postoperative complications. Data were using fixed-effects or random-effects models with standard mean differences and risk ratios for continuous and dichotomous variables, respectively.Finally, 9 clinical studies with 744 patients were included in this meta-analysis. Compared with the control group, TXA group could reduced transfusion rate, dominant blood loss, postoperative drainage volume, hidden blood loss, and total blood loss, and increased postoperative HB with statistically significance.The main findings of this meta-analysis are that the transfusion rate, dominant blood loss, postoperative drainage volume, hidden blood loss, total blood loss and postoperative HB in the tranexamic acid group were superior to those in the routine group. Additional high-quality RCTs should be conducted in the future.http://www.sciencedirect.com/science/article/pii/S1015958422015123Unicompartmental knee arthroplastyMeta-analysisTranexamic acid |
| spellingShingle | Nengyuan Weng Yawei Gou Fuguo Kuang Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis Asian Journal of Surgery Unicompartmental knee arthroplasty Meta-analysis Tranexamic acid |
| title | Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis |
| title_full | Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis |
| title_short | Efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty: A systematic review and meta-analysis |
| title_sort | efficacy and safety of tranexamic acid in unicompartmental knee arthroplasty a systematic review and meta analysis |
| topic | Unicompartmental knee arthroplasty Meta-analysis Tranexamic acid |
| url | http://www.sciencedirect.com/science/article/pii/S1015958422015123 |
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