The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease
The aim of the study was to analyze the effect of polymorphic variants previously associated with arterial hypertension (AH) in Genome Wide Association Studies (GWASs) in/next to genes and locuses CYP7A1 and PLEKHA7 on the development of coronary artery disease (CAD) in Bulgarian patients. A hundred...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
| Almmustuhtton: |
Sciendo
2022-12-01
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| Ráidu: | Acta Medica Bulgarica |
| Fáttát: | |
| Liŋkkat: | https://doi.org/10.2478/amb-2022-0034 |
| _version_ | 1827815270616399872 |
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| author | Yaneva-Sirakova T. Kaneva R. Tzveova R. Bozhilova R. Popov I. Shumkova M. Hristova I. Vassilev D. |
| author_facet | Yaneva-Sirakova T. Kaneva R. Tzveova R. Bozhilova R. Popov I. Shumkova M. Hristova I. Vassilev D. |
| author_sort | Yaneva-Sirakova T. |
| collection | DOAJ |
| description | The aim of the study was to analyze the effect of polymorphic variants previously associated with arterial hypertension (AH) in Genome Wide Association Studies (GWASs) in/next to genes and locuses CYP7A1 and PLEKHA7 on the development of coronary artery disease (CAD) in Bulgarian patients. A hundred and nine consecutive patients with angiographically documented CAD were studied. The genotyping was done with 7900 HT Fast Real-Time PCR (Applied Biosystems) with TaqMan® method. The control group consisted of 192 healthy population controls, selected from the bio- bank of the Molecular Medicine Center. SPSS and PLINK were used for the statistical analysis with level of significance < 0.05 and confidence interval 95%. The mean age of the studied patients was 63.71 ± 9.35 years; 35 (35%) females. Previous myocardial infarction (MI) had 38(38%); one-vessel – 39 (39%); two-vessel – 28 (28%); three-vessel disease – 34 (34%); 43 (43%) were with diabetes mellitus; 92 (92%) – with arterial hypertension (AH); 77 (77%) – with dyslipidemia; 42 (42%) were smokers; 25 (25%) were obese. We did not find any significant association between CAD and poly- morphism rs11191548 near CYP17A1 and only a tendency for genotype of rs381815 in PLEKHA7 (p = 0.06; OR 0.64; CI 0.40-1.02 for CAD) under dominant model. This is of practical importance both for studying the genetic aspects of CAD in the future and for enlargement of the current database. |
| first_indexed | 2024-03-11T23:57:48Z |
| format | Article |
| id | doaj.art-09133f5117404c56b231769129db9d57 |
| institution | Directory Open Access Journal |
| issn | 2719-5384 |
| language | English |
| last_indexed | 2024-03-11T23:57:48Z |
| publishDate | 2022-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Bulgarica |
| spelling | doaj.art-09133f5117404c56b231769129db9d572023-09-18T06:32:59ZengSciendoActa Medica Bulgarica2719-53842022-12-0149451110.2478/amb-2022-0034The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery DiseaseYaneva-Sirakova T.0Kaneva R.1Tzveova R.2Bozhilova R.3Popov I.4Shumkova M.5Hristova I.6Vassilev D.7Department of Internal Medicine, Medical Faculty, Medical University – Sofia, Cardiology Clinic UMHAT “Alexandrovska” – Sofia, BulgariaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Medical University – Sofia, Molecular Medicine Center – Sofia, BulgariaDepartment of General and Clinical Pathology, UMHAT “Tsaritsa Yoanna – ISUL” – Sofia, BulgariaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Medical University – Sofia, Molecular Medicine Center – Sofia, BulgariaDepartment of Medical Chemistry and Biochemistry, Medical Faculty, Medical University – Sofia, Molecular Medicine Center – Sofia, BulgariaDepartment of Internal Medicine, Medical Faculty, Medical University – Sofia, Cardiology Clinic UMHAT “Alexandrovska” – Sofia, BulgariaAcibadem City Clinic Cardiovascular Center – Sofia, BulgariaDepartment of Internal Medicine, Medical Faculty, Medical University – Sofia, Cardiology Clinic UMHAT “Alexandrovska” – Sofia, BulgariaThe aim of the study was to analyze the effect of polymorphic variants previously associated with arterial hypertension (AH) in Genome Wide Association Studies (GWASs) in/next to genes and locuses CYP7A1 and PLEKHA7 on the development of coronary artery disease (CAD) in Bulgarian patients. A hundred and nine consecutive patients with angiographically documented CAD were studied. The genotyping was done with 7900 HT Fast Real-Time PCR (Applied Biosystems) with TaqMan® method. The control group consisted of 192 healthy population controls, selected from the bio- bank of the Molecular Medicine Center. SPSS and PLINK were used for the statistical analysis with level of significance < 0.05 and confidence interval 95%. The mean age of the studied patients was 63.71 ± 9.35 years; 35 (35%) females. Previous myocardial infarction (MI) had 38(38%); one-vessel – 39 (39%); two-vessel – 28 (28%); three-vessel disease – 34 (34%); 43 (43%) were with diabetes mellitus; 92 (92%) – with arterial hypertension (AH); 77 (77%) – with dyslipidemia; 42 (42%) were smokers; 25 (25%) were obese. We did not find any significant association between CAD and poly- morphism rs11191548 near CYP17A1 and only a tendency for genotype of rs381815 in PLEKHA7 (p = 0.06; OR 0.64; CI 0.40-1.02 for CAD) under dominant model. This is of practical importance both for studying the genetic aspects of CAD in the future and for enlargement of the current database.https://doi.org/10.2478/amb-2022-0034coronary artery diseaseplekha7cyp17a1steroid hormonesca2+ exchangearterial hypertension |
| spellingShingle | Yaneva-Sirakova T. Kaneva R. Tzveova R. Bozhilova R. Popov I. Shumkova M. Hristova I. Vassilev D. The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease Acta Medica Bulgarica coronary artery disease plekha7 cyp17a1 steroid hormones ca2+ exchange arterial hypertension |
| title | The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease |
| title_full | The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease |
| title_fullStr | The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease |
| title_full_unstemmed | The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease |
| title_short | The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease |
| title_sort | role of certain polymorphic variants in genes previously associated with blood pressure values with reference to the risk of development of coronary artery disease |
| topic | coronary artery disease plekha7 cyp17a1 steroid hormones ca2+ exchange arterial hypertension |
| url | https://doi.org/10.2478/amb-2022-0034 |
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