Antibody Targeting of Eph Receptors in Cancer
The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated or progenitor cells in tumors and the tumor microe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/13/5/88 |
| _version_ | 1797568584862400512 |
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| author | Peter W. Janes Mary E. Vail Hui K. Gan Andrew M. Scott |
| author_facet | Peter W. Janes Mary E. Vail Hui K. Gan Andrew M. Scott |
| author_sort | Peter W. Janes |
| collection | DOAJ |
| description | The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated or progenitor cells in tumors and the tumor microenvironment, associated with tumor initiation, angiogenesis and metastasis. Eph receptors are thus attractive therapeutic targets, and monoclonal antibodies have been commonly developed and tested for anti-cancer activity in preclinical models, and in some cases in the clinic. This review summarizes 20 years of research on various antibody-based approaches to target Eph receptors in tumors and the tumor microenvironment, including their mode of action, tumor specificity, and efficacy in pre-clinical and clinical testing. |
| first_indexed | 2024-03-10T19:58:04Z |
| format | Article |
| id | doaj.art-09149a8f336840329bd807b6ed6cd181 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T19:58:04Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-09149a8f336840329bd807b6ed6cd1812023-11-19T23:45:21ZengMDPI AGPharmaceuticals1424-82472020-05-011358810.3390/ph13050088Antibody Targeting of Eph Receptors in CancerPeter W. Janes0Mary E. Vail1Hui K. Gan2Andrew M. Scott3Olivia Newton-John Cancer Institute and La Trobe University School of Cancer Medicine, Victoria 3084, AustraliaOlivia Newton-John Cancer Institute and La Trobe University School of Cancer Medicine, Victoria 3084, AustraliaOlivia Newton-John Cancer Institute and La Trobe University School of Cancer Medicine, Victoria 3084, AustraliaOlivia Newton-John Cancer Institute and La Trobe University School of Cancer Medicine, Victoria 3084, AustraliaThe Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated or progenitor cells in tumors and the tumor microenvironment, associated with tumor initiation, angiogenesis and metastasis. Eph receptors are thus attractive therapeutic targets, and monoclonal antibodies have been commonly developed and tested for anti-cancer activity in preclinical models, and in some cases in the clinic. This review summarizes 20 years of research on various antibody-based approaches to target Eph receptors in tumors and the tumor microenvironment, including their mode of action, tumor specificity, and efficacy in pre-clinical and clinical testing.https://www.mdpi.com/1424-8247/13/5/88Eph receptortherapeutic antibodiescancer |
| spellingShingle | Peter W. Janes Mary E. Vail Hui K. Gan Andrew M. Scott Antibody Targeting of Eph Receptors in Cancer Pharmaceuticals Eph receptor therapeutic antibodies cancer |
| title | Antibody Targeting of Eph Receptors in Cancer |
| title_full | Antibody Targeting of Eph Receptors in Cancer |
| title_fullStr | Antibody Targeting of Eph Receptors in Cancer |
| title_full_unstemmed | Antibody Targeting of Eph Receptors in Cancer |
| title_short | Antibody Targeting of Eph Receptors in Cancer |
| title_sort | antibody targeting of eph receptors in cancer |
| topic | Eph receptor therapeutic antibodies cancer |
| url | https://www.mdpi.com/1424-8247/13/5/88 |
| work_keys_str_mv | AT peterwjanes antibodytargetingofephreceptorsincancer AT maryevail antibodytargetingofephreceptorsincancer AT huikgan antibodytargetingofephreceptorsincancer AT andrewmscott antibodytargetingofephreceptorsincancer |