Electrical stimulation therapy for peripheral nerve injury
Peripheral nerve injury is common and frequently occurs in extremity trauma patients. The motor and sensory impairment caused by the injury will affect patients' daily life and social work. Surgical therapeutic approaches don't assure functional recovery, which may lead to neuronal atrophy...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1081458/full |
| _version_ | 1828005094738624512 |
|---|---|
| author | Lingmei Ni Zhao Yao Yifan Zhao Tianfang Zhang Jie Wang Siyue Li Zuobing Chen Zuobing Chen |
| author_facet | Lingmei Ni Zhao Yao Yifan Zhao Tianfang Zhang Jie Wang Siyue Li Zuobing Chen Zuobing Chen |
| author_sort | Lingmei Ni |
| collection | DOAJ |
| description | Peripheral nerve injury is common and frequently occurs in extremity trauma patients. The motor and sensory impairment caused by the injury will affect patients' daily life and social work. Surgical therapeutic approaches don't assure functional recovery, which may lead to neuronal atrophy and hinder accelerated regeneration. Rehabilitation is a necessary stage for patients to recover better. A meaningful role in non-pharmacological intervention is played by rehabilitation, through individualized electrical stimulation therapy. Clinical studies have shown that electrical stimulation enhances axon growth during nerve repair and accelerates sensorimotor recovery. According to different effects and parameters, electrical stimulation can be divided into neuromuscular, transcutaneous, and functional electrical stimulation. The therapeutic mechanism of electrical stimulation may be to reduce muscle atrophy and promote muscle reinnervation by increasing the expression of structural protective proteins and neurotrophic factors. Meanwhile, it can modulate sensory feedback and reduce neuralgia by inhibiting the descending pathway. However, there are not many summary clinical application parameters of electrical stimulation, and the long-term effectiveness and safety also need to be further explored. This article aims to explore application methodologies for effective electrical stimulation in the rehabilitation of peripheral nerve injury, with simultaneous consideration for fundamental principles of electrical stimulation and the latest technology. The highlight of this paper is to identify the most appropriate stimulation parameters (frequency, intensity, duration) to achieve efficacious electrical stimulation in the rehabilitation of peripheral nerve injury. |
| first_indexed | 2024-04-10T07:25:48Z |
| format | Article |
| id | doaj.art-0917c7f4913f4caa977c19d666bb7016 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T07:25:48Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0917c7f4913f4caa977c19d666bb70162023-02-24T05:45:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.10814581081458Electrical stimulation therapy for peripheral nerve injuryLingmei Ni0Zhao Yao1Yifan Zhao2Tianfang Zhang3Jie Wang4Siyue Li5Zuobing Chen6Zuobing Chen7Infection Prevention and Control Department, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaPeripheral nerve injury is common and frequently occurs in extremity trauma patients. The motor and sensory impairment caused by the injury will affect patients' daily life and social work. Surgical therapeutic approaches don't assure functional recovery, which may lead to neuronal atrophy and hinder accelerated regeneration. Rehabilitation is a necessary stage for patients to recover better. A meaningful role in non-pharmacological intervention is played by rehabilitation, through individualized electrical stimulation therapy. Clinical studies have shown that electrical stimulation enhances axon growth during nerve repair and accelerates sensorimotor recovery. According to different effects and parameters, electrical stimulation can be divided into neuromuscular, transcutaneous, and functional electrical stimulation. The therapeutic mechanism of electrical stimulation may be to reduce muscle atrophy and promote muscle reinnervation by increasing the expression of structural protective proteins and neurotrophic factors. Meanwhile, it can modulate sensory feedback and reduce neuralgia by inhibiting the descending pathway. However, there are not many summary clinical application parameters of electrical stimulation, and the long-term effectiveness and safety also need to be further explored. This article aims to explore application methodologies for effective electrical stimulation in the rehabilitation of peripheral nerve injury, with simultaneous consideration for fundamental principles of electrical stimulation and the latest technology. The highlight of this paper is to identify the most appropriate stimulation parameters (frequency, intensity, duration) to achieve efficacious electrical stimulation in the rehabilitation of peripheral nerve injury.https://www.frontiersin.org/articles/10.3389/fneur.2023.1081458/fullperipheral nerve injuryperipheral nerve regenerationelectrical stimulation (ES)therapymechanism |
| spellingShingle | Lingmei Ni Zhao Yao Yifan Zhao Tianfang Zhang Jie Wang Siyue Li Zuobing Chen Zuobing Chen Electrical stimulation therapy for peripheral nerve injury Frontiers in Neurology peripheral nerve injury peripheral nerve regeneration electrical stimulation (ES) therapy mechanism |
| title | Electrical stimulation therapy for peripheral nerve injury |
| title_full | Electrical stimulation therapy for peripheral nerve injury |
| title_fullStr | Electrical stimulation therapy for peripheral nerve injury |
| title_full_unstemmed | Electrical stimulation therapy for peripheral nerve injury |
| title_short | Electrical stimulation therapy for peripheral nerve injury |
| title_sort | electrical stimulation therapy for peripheral nerve injury |
| topic | peripheral nerve injury peripheral nerve regeneration electrical stimulation (ES) therapy mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1081458/full |
| work_keys_str_mv | AT lingmeini electricalstimulationtherapyforperipheralnerveinjury AT zhaoyao electricalstimulationtherapyforperipheralnerveinjury AT yifanzhao electricalstimulationtherapyforperipheralnerveinjury AT tianfangzhang electricalstimulationtherapyforperipheralnerveinjury AT jiewang electricalstimulationtherapyforperipheralnerveinjury AT siyueli electricalstimulationtherapyforperipheralnerveinjury AT zuobingchen electricalstimulationtherapyforperipheralnerveinjury AT zuobingchen electricalstimulationtherapyforperipheralnerveinjury |