Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use
Undifferentiated pleomorphic sarcoma (UPS), a subtype of soft tissue sarcoma (STS), is an uncommon malignancy associated with a poor prognosis. As with other forms of sarcoma, surgical resection remains the only form of treatment with curative potential. The role of perioperative systemic therapy ha...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1198292/full |
| _version_ | 1797796638486429696 |
|---|---|
| author | Won Jin Jeon Jin Hyun Moon Bryan Pham Bowon Joung Laura Denham Joel Brothers |
| author_facet | Won Jin Jeon Jin Hyun Moon Bryan Pham Bowon Joung Laura Denham Joel Brothers |
| author_sort | Won Jin Jeon |
| collection | DOAJ |
| description | Undifferentiated pleomorphic sarcoma (UPS), a subtype of soft tissue sarcoma (STS), is an uncommon malignancy associated with a poor prognosis. As with other forms of sarcoma, surgical resection remains the only form of treatment with curative potential. The role of perioperative systemic therapy has not been definitively elucidated. Due to high recurrence rates and metastatic potential, management of UPS can pose a difficult task for clinicians. In cases of unresectable UPS due to anatomic limitations and in patients with comorbidities and poor performance status (PS), management options are limited. We describe a patient with UPS involving the chest wall with poor PS who achieved complete response (CR) following neoadjuvant chemotherapy and radiation in the setting of prior immune-checkpoint inhibitor (ICI) therapy. |
| first_indexed | 2024-03-13T03:37:03Z |
| format | Article |
| id | doaj.art-09198af9a5424caf86f0ffb853df6fee |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T03:37:03Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-09198af9a5424caf86f0ffb853df6fee2023-06-23T16:02:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11982921198292Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor useWon Jin Jeon0Jin Hyun Moon1Bryan Pham2Bowon Joung3Laura Denham4Joel Brothers5Department of Internal Medicine, Loma Linda University, Loma Linda, CA, United StatesDepartment of Internal Medicine, Loma Linda University, Loma Linda, CA, United StatesDepartment of Internal Medicine, Loma Linda University, Loma Linda, CA, United StatesDepartment of Internal Medicine, Loma Linda University, Loma Linda, CA, United StatesDepartment of Anatomic and Clinical Pathology, Loma Linda University, Loma Linda, CA, United StatesDivision of Medical Oncology and Hematology, Department of Internal Medicine, Loma Linda University, Loma Linda, CA, United StatesUndifferentiated pleomorphic sarcoma (UPS), a subtype of soft tissue sarcoma (STS), is an uncommon malignancy associated with a poor prognosis. As with other forms of sarcoma, surgical resection remains the only form of treatment with curative potential. The role of perioperative systemic therapy has not been definitively elucidated. Due to high recurrence rates and metastatic potential, management of UPS can pose a difficult task for clinicians. In cases of unresectable UPS due to anatomic limitations and in patients with comorbidities and poor performance status (PS), management options are limited. We describe a patient with UPS involving the chest wall with poor PS who achieved complete response (CR) following neoadjuvant chemotherapy and radiation in the setting of prior immune-checkpoint inhibitor (ICI) therapy.https://www.frontiersin.org/articles/10.3389/fonc.2023.1198292/fullundifferentiated pleomorphic sarcoma (UPS)immune-checkpoint inhibitor (ICI)perioperative therapytumor microenvironmentneoadjuvant therapy |
| spellingShingle | Won Jin Jeon Jin Hyun Moon Bryan Pham Bowon Joung Laura Denham Joel Brothers Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use Frontiers in Oncology undifferentiated pleomorphic sarcoma (UPS) immune-checkpoint inhibitor (ICI) perioperative therapy tumor microenvironment neoadjuvant therapy |
| title | Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use |
| title_full | Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use |
| title_fullStr | Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use |
| title_full_unstemmed | Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use |
| title_short | Case Report: An exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use |
| title_sort | case report an exceptional response to neoadjuvant radiotherapy and chemotherapy in undifferentiated pleomorphic sarcoma following checkpoint inhibitor use |
| topic | undifferentiated pleomorphic sarcoma (UPS) immune-checkpoint inhibitor (ICI) perioperative therapy tumor microenvironment neoadjuvant therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1198292/full |
| work_keys_str_mv | AT wonjinjeon casereportanexceptionalresponsetoneoadjuvantradiotherapyandchemotherapyinundifferentiatedpleomorphicsarcomafollowingcheckpointinhibitoruse AT jinhyunmoon casereportanexceptionalresponsetoneoadjuvantradiotherapyandchemotherapyinundifferentiatedpleomorphicsarcomafollowingcheckpointinhibitoruse AT bryanpham casereportanexceptionalresponsetoneoadjuvantradiotherapyandchemotherapyinundifferentiatedpleomorphicsarcomafollowingcheckpointinhibitoruse AT bowonjoung casereportanexceptionalresponsetoneoadjuvantradiotherapyandchemotherapyinundifferentiatedpleomorphicsarcomafollowingcheckpointinhibitoruse AT lauradenham casereportanexceptionalresponsetoneoadjuvantradiotherapyandchemotherapyinundifferentiatedpleomorphicsarcomafollowingcheckpointinhibitoruse AT joelbrothers casereportanexceptionalresponsetoneoadjuvantradiotherapyandchemotherapyinundifferentiatedpleomorphicsarcomafollowingcheckpointinhibitoruse |