Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging
Background and objective: To evaluate the reliability of compressed-sensing (CS) real-time single-breath-hold cine imaging for quantification of right ventricular (RV) function and volumes in congenital heart disease (CHD) patients in comparison with the standard multi-breath-hold technique. Methods...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/9/1930 |
| _version_ | 1797535752912896000 |
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| author | Benjamin Longère Julien Pagniez Augustin Coisne Hedi Farah Michaela Schmidt Christoph Forman Valentina Silvestri Arianna Simeone Christos V Gkizas Justin Hennicaux Emma Cheasty Solenn Toupin David Montaigne François Pontana |
| author_facet | Benjamin Longère Julien Pagniez Augustin Coisne Hedi Farah Michaela Schmidt Christoph Forman Valentina Silvestri Arianna Simeone Christos V Gkizas Justin Hennicaux Emma Cheasty Solenn Toupin David Montaigne François Pontana |
| author_sort | Benjamin Longère |
| collection | DOAJ |
| description | Background and objective: To evaluate the reliability of compressed-sensing (CS) real-time single-breath-hold cine imaging for quantification of right ventricular (RV) function and volumes in congenital heart disease (CHD) patients in comparison with the standard multi-breath-hold technique. Methods: Sixty-one consecutive CHD patients (mean age = 22.2 ± 9.0 (SD) years) were prospectively evaluated during either the initial work-up or after repair. For each patient, two series of cine images were acquired: first, the reference segmented multi-breath-hold steady-state free-precession sequence (SSFP<sub>ref</sub>), including a short-axis stack, one four-chamber slice, and one long-axis slice; then, an additional real-time compressed-sensing single-breath-hold sequence (CS<sub>rt</sub>) providing the same slices. Two radiologists independently assessed the image quality and RV volumes for both techniques, which were compared using the Wilcoxon test and paired Student’s <i>t</i> test, Bland–Altman, and linear regression analyses. The visualization of wall-motion disorders and tricuspid-regurgitation-related signal voids were also analyzed. Results: The mean acquisition time for CS<sub>rt</sub> was 22.4 ± 6.2 (SD) s (95% CI: 20.8–23.9 s) versus 442.2 ± 89.9 (SD) s (95% CI: 419.2–465.2 s) for SSFP<sub>ref</sub> (<i>p</i> < 0.001). The image quality of CS<sub>rt</sub> was diagnostic in all examinations and was mostly rated as good (<i>n</i> = 49/61; 80.3%). There was a high correlation between SSFP<sub>ref</sub> and CS<sub>rt</sub> images regarding RV ejection fraction (49.8 ± 7.8 (SD)% (95% CI: 47.8–51.8%) versus 48.7 ± 8.6 (SD)% (95% CI: 46.5–50.9%), respectively; <i>r</i> = 0.94) and RV end-diastolic volume (192.9 ± 60.1 (SD) mL (95% CI: 177.5–208.3 mL) versus 194.9 ± 62.1 (SD) mL (95% CI: 179.0–210.8 mL), respectively; <i>r</i> = 0.98). In CS<sub>rt</sub> images, tricuspid-regurgitation and wall-motion disorder visualization was good (area under receiver operating characteristic curve (AUC) = 0.87) and excellent (AUC = 1), respectively. Conclusions: Compressed-sensing real-time cine imaging enables, in one breath hold, an accurate assessment of RV function and volumes in CHD patients in comparison with standard SSFP<sub>ref</sub>, allowing a substantial improvement in time efficiency. |
| first_indexed | 2024-03-10T11:48:47Z |
| format | Article |
| id | doaj.art-0919d09b74494a929f09215d97d50f44 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:48:47Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0919d09b74494a929f09215d97d50f442023-11-21T17:49:18ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01109193010.3390/jcm10091930Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine ImagingBenjamin Longère0Julien Pagniez1Augustin Coisne2Hedi Farah3Michaela Schmidt4Christoph Forman5Valentina Silvestri6Arianna Simeone7Christos V Gkizas8Justin Hennicaux9Emma Cheasty10Solenn Toupin11David Montaigne12François Pontana13University of Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1011—European Genomic Institute for Diabetes (EGID), F-59000 Lille, FranceCHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, FranceUniversity of Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1011—European Genomic Institute for Diabetes (EGID), F-59000 Lille, FranceCHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, FranceMR Product Innovation and Definition, Magnetic Resonance, Siemens Healthcare GmbH, 91052 Erlangen, GermanyMR Product Innovation and Definition, Magnetic Resonance, Siemens Healthcare GmbH, 91052 Erlangen, GermanyCHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, FranceCHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, FranceCHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, FranceCHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, FranceDepartment of Cardiovascular Imaging, St Bartholomew’s Hospital, West Smithfield, London EC1A 7BE, UKScientific Partnerships, Siemens Healthcare France, 93200 Saint-Denis, FranceUniversity of Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1011—European Genomic Institute for Diabetes (EGID), F-59000 Lille, FranceUniversity of Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1011—European Genomic Institute for Diabetes (EGID), F-59000 Lille, FranceBackground and objective: To evaluate the reliability of compressed-sensing (CS) real-time single-breath-hold cine imaging for quantification of right ventricular (RV) function and volumes in congenital heart disease (CHD) patients in comparison with the standard multi-breath-hold technique. Methods: Sixty-one consecutive CHD patients (mean age = 22.2 ± 9.0 (SD) years) were prospectively evaluated during either the initial work-up or after repair. For each patient, two series of cine images were acquired: first, the reference segmented multi-breath-hold steady-state free-precession sequence (SSFP<sub>ref</sub>), including a short-axis stack, one four-chamber slice, and one long-axis slice; then, an additional real-time compressed-sensing single-breath-hold sequence (CS<sub>rt</sub>) providing the same slices. Two radiologists independently assessed the image quality and RV volumes for both techniques, which were compared using the Wilcoxon test and paired Student’s <i>t</i> test, Bland–Altman, and linear regression analyses. The visualization of wall-motion disorders and tricuspid-regurgitation-related signal voids were also analyzed. Results: The mean acquisition time for CS<sub>rt</sub> was 22.4 ± 6.2 (SD) s (95% CI: 20.8–23.9 s) versus 442.2 ± 89.9 (SD) s (95% CI: 419.2–465.2 s) for SSFP<sub>ref</sub> (<i>p</i> < 0.001). The image quality of CS<sub>rt</sub> was diagnostic in all examinations and was mostly rated as good (<i>n</i> = 49/61; 80.3%). There was a high correlation between SSFP<sub>ref</sub> and CS<sub>rt</sub> images regarding RV ejection fraction (49.8 ± 7.8 (SD)% (95% CI: 47.8–51.8%) versus 48.7 ± 8.6 (SD)% (95% CI: 46.5–50.9%), respectively; <i>r</i> = 0.94) and RV end-diastolic volume (192.9 ± 60.1 (SD) mL (95% CI: 177.5–208.3 mL) versus 194.9 ± 62.1 (SD) mL (95% CI: 179.0–210.8 mL), respectively; <i>r</i> = 0.98). In CS<sub>rt</sub> images, tricuspid-regurgitation and wall-motion disorder visualization was good (area under receiver operating characteristic curve (AUC) = 0.87) and excellent (AUC = 1), respectively. Conclusions: Compressed-sensing real-time cine imaging enables, in one breath hold, an accurate assessment of RV function and volumes in CHD patients in comparison with standard SSFP<sub>ref</sub>, allowing a substantial improvement in time efficiency.https://www.mdpi.com/2077-0383/10/9/1930cardiacheartmagnetic resonanceCMRcompressed sensingcongenital heart disease |
| spellingShingle | Benjamin Longère Julien Pagniez Augustin Coisne Hedi Farah Michaela Schmidt Christoph Forman Valentina Silvestri Arianna Simeone Christos V Gkizas Justin Hennicaux Emma Cheasty Solenn Toupin David Montaigne François Pontana Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging Journal of Clinical Medicine cardiac heart magnetic resonance CMR compressed sensing congenital heart disease |
| title | Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging |
| title_full | Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging |
| title_fullStr | Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging |
| title_full_unstemmed | Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging |
| title_short | Right Ventricular Volume and Function Assessment in Congenital Heart Disease Using CMR Compressed-Sensing Real-Time Cine Imaging |
| title_sort | right ventricular volume and function assessment in congenital heart disease using cmr compressed sensing real time cine imaging |
| topic | cardiac heart magnetic resonance CMR compressed sensing congenital heart disease |
| url | https://www.mdpi.com/2077-0383/10/9/1930 |
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