The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers
Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also plays a crucial role in inflammation control...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020304564 |
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| author | Khalil Hajiasgharzadeh Mohammad Hossein Somi Saeed Sadigh-Eteghad Ahad Mokhtarzadeh Dariush Shanehbandi Behzad Mansoori Ali Mohammadi Mohammad Amin Doustvandi Behzad Baradaran |
| author_facet | Khalil Hajiasgharzadeh Mohammad Hossein Somi Saeed Sadigh-Eteghad Ahad Mokhtarzadeh Dariush Shanehbandi Behzad Mansoori Ali Mohammadi Mohammad Amin Doustvandi Behzad Baradaran |
| author_sort | Khalil Hajiasgharzadeh |
| collection | DOAJ |
| description | Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also plays a crucial role in inflammation control through the cholinergic anti-inflammatory pathway in numerous pathophysiological contexts. Such diverse physiological and pathological functions that initiate from this receptor may have significant impacts in determining the outcome of different cancers. Various tissues of gastrointestinal (GI) cancers such as gastric, colorectal, pancreatic and liver cancers have shown the up-regulated expression of α7nAChR as compared to normal adjacent tissues. According to the well-established connection between inflammation and tumorigenesis in the digestive system, there are mounting studies demonstrated either stimulatory or inhibitory effects of α7nAChR signaling in the development of GI cancers. To date, the precise underlying mechanisms related to this receptor in patients with GI cancers have not been fully elucidated. Regarding the paradoxical modulatory effects of this receptor in carcinogenesis, in this review, we aim to summarize the accumulated evidence about the involvement of α7nAChR in inflammation-associated GI cancers. It seems that the complex influences of α7nAChR may be a promising target in designing novel strategies in the treatment of such pathologic conditions. |
| first_indexed | 2024-12-11T11:33:39Z |
| format | Article |
| id | doaj.art-091afce23dda40bea325ce8a75a68624 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-11T11:33:39Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-091afce23dda40bea325ce8a75a686242022-12-22T01:08:48ZengElsevierHeliyon2405-84402020-03-0163e03611The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancersKhalil Hajiasgharzadeh0Mohammad Hossein Somi1Saeed Sadigh-Eteghad2Ahad Mokhtarzadeh3Dariush Shanehbandi4Behzad Mansoori5Ali Mohammadi6Mohammad Amin Doustvandi7Behzad Baradaran8Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranLiver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DenmarkImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author.Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also plays a crucial role in inflammation control through the cholinergic anti-inflammatory pathway in numerous pathophysiological contexts. Such diverse physiological and pathological functions that initiate from this receptor may have significant impacts in determining the outcome of different cancers. Various tissues of gastrointestinal (GI) cancers such as gastric, colorectal, pancreatic and liver cancers have shown the up-regulated expression of α7nAChR as compared to normal adjacent tissues. According to the well-established connection between inflammation and tumorigenesis in the digestive system, there are mounting studies demonstrated either stimulatory or inhibitory effects of α7nAChR signaling in the development of GI cancers. To date, the precise underlying mechanisms related to this receptor in patients with GI cancers have not been fully elucidated. Regarding the paradoxical modulatory effects of this receptor in carcinogenesis, in this review, we aim to summarize the accumulated evidence about the involvement of α7nAChR in inflammation-associated GI cancers. It seems that the complex influences of α7nAChR may be a promising target in designing novel strategies in the treatment of such pathologic conditions.http://www.sciencedirect.com/science/article/pii/S2405844020304564Clinical researchGastrointestinal systemImmunologyOncologyPharmacologyPhysiology |
| spellingShingle | Khalil Hajiasgharzadeh Mohammad Hossein Somi Saeed Sadigh-Eteghad Ahad Mokhtarzadeh Dariush Shanehbandi Behzad Mansoori Ali Mohammadi Mohammad Amin Doustvandi Behzad Baradaran The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers Heliyon Clinical research Gastrointestinal system Immunology Oncology Pharmacology Physiology |
| title | The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers |
| title_full | The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers |
| title_fullStr | The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers |
| title_full_unstemmed | The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers |
| title_short | The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers |
| title_sort | dual role of alpha7 nicotinic acetylcholine receptor in inflammation associated gastrointestinal cancers |
| topic | Clinical research Gastrointestinal system Immunology Oncology Pharmacology Physiology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020304564 |
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