Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis
Objective: A network meta-analysis based on randomized controlled trials was conducted to investigate the effects of pharmacological interventions on smoking cessation.Methods: English databases were searched to obtain randomized controlled trials reporting the effect of pharmacological intervention...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1012433/full |
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| author | Xue Shang Xue Shang Xue Shang Kangle Guo Kangle Guo Kangle Guo Fenfen E. Fenfen E. Fenfen E. Xinxin Deng Xinxin Deng Xinxin Deng Yongsheng Wang Yongsheng Wang Yongsheng Wang Ziyi Wang Ziyi Wang Ziyi Wang Yanan Wu Yanan Wu Yanan Wu Meng Xu Meng Xu Meng Xu Chaoqun Yang Chaoqun Yang Chaoqun Yang Xiuxia Li Xiuxia Li Xiuxia Li Kehu Yang Kehu Yang Kehu Yang |
| author_facet | Xue Shang Xue Shang Xue Shang Kangle Guo Kangle Guo Kangle Guo Fenfen E. Fenfen E. Fenfen E. Xinxin Deng Xinxin Deng Xinxin Deng Yongsheng Wang Yongsheng Wang Yongsheng Wang Ziyi Wang Ziyi Wang Ziyi Wang Yanan Wu Yanan Wu Yanan Wu Meng Xu Meng Xu Meng Xu Chaoqun Yang Chaoqun Yang Chaoqun Yang Xiuxia Li Xiuxia Li Xiuxia Li Kehu Yang Kehu Yang Kehu Yang |
| author_sort | Xue Shang |
| collection | DOAJ |
| description | Objective: A network meta-analysis based on randomized controlled trials was conducted to investigate the effects of pharmacological interventions on smoking cessation.Methods: English databases were searched to obtain randomized controlled trials reporting the effect of pharmacological interventions on smoking cessation. The risk of bias for the included trials was assessed using Cochrane Handbook tool. Stata 15.1 software was used to perform network meta-analysis, and GRADE approach was used to assess the evidence credibility on the effects of different interventions on smoking cessation.Results: A total of 159 studies involving 60,285 smokers were included in the network meta-analysis. The analysis involved 15 interventions and which yielded 105 pairs of comparisons. Network meta-analysis showed that varenicline was more helpful for smoking cessation than other monotherapies, such as nicotine replacement therapy [Odds Ratio (OR) = 1.42, 95% confidence interval (CI) (1.16, 1.73)] and bupropion [OR = 1.52, 95% CI (1.22, 1.89)]. Furthermore, combined interventions were superior to monotherapy in achieving smoking cessation, such as varenicline plus bupropion over bupropion [OR = 2.00, 95% CI (1.11, 3.61)], varenicline plus nicotine replacement therapy over nicotine replacement therapy [OR = 1.84, 95% CI (1.07, 3.18)], and nicotine replacement therapy plus mecamylamine over naltrexone [OR = 6.29, 95% CI (1.59, 24.90)]. Finally, the surface under the cumulative ranking curve value indicated that nicotine replacement therapy plus mecamylamine had the greatest probability of becoming the best intervention.Conclusion: Most pharmacological interventions demonstrated a benefit in smoking cessation compared with placebo, whether monotherapy or combination therapy. Moreover, confirmed evidence suggested that some combination treatments, such as varenicline plus bupropion and nicotine replacement therapy plus mecamylamine have a higher probability of being the best smoking cessation in |
| first_indexed | 2024-04-13T22:28:19Z |
| format | Article |
| id | doaj.art-091c9dc829f6474abbbf8960dc8f6c82 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T22:28:19Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-091c9dc829f6474abbbf8960dc8f6c822022-12-22T02:27:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10124331012433Pharmacological interventions on smoking cessation: A systematic review and network meta-analysisXue Shang0Xue Shang1Xue Shang2Kangle Guo3Kangle Guo4Kangle Guo5Fenfen E.6Fenfen E.7Fenfen E.8Xinxin Deng9Xinxin Deng10Xinxin Deng11Yongsheng Wang12Yongsheng Wang13Yongsheng Wang14Ziyi Wang15Ziyi Wang16Ziyi Wang17Yanan Wu18Yanan Wu19Yanan Wu20Meng Xu21Meng Xu22Meng Xu23Chaoqun Yang24Chaoqun Yang25Chaoqun Yang26Xiuxia Li27Xiuxia Li28Xiuxia Li29Kehu Yang30Kehu Yang31Kehu Yang32Health Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaGansu Provincial Hospital, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaHealth Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaKey Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, ChinaObjective: A network meta-analysis based on randomized controlled trials was conducted to investigate the effects of pharmacological interventions on smoking cessation.Methods: English databases were searched to obtain randomized controlled trials reporting the effect of pharmacological interventions on smoking cessation. The risk of bias for the included trials was assessed using Cochrane Handbook tool. Stata 15.1 software was used to perform network meta-analysis, and GRADE approach was used to assess the evidence credibility on the effects of different interventions on smoking cessation.Results: A total of 159 studies involving 60,285 smokers were included in the network meta-analysis. The analysis involved 15 interventions and which yielded 105 pairs of comparisons. Network meta-analysis showed that varenicline was more helpful for smoking cessation than other monotherapies, such as nicotine replacement therapy [Odds Ratio (OR) = 1.42, 95% confidence interval (CI) (1.16, 1.73)] and bupropion [OR = 1.52, 95% CI (1.22, 1.89)]. Furthermore, combined interventions were superior to monotherapy in achieving smoking cessation, such as varenicline plus bupropion over bupropion [OR = 2.00, 95% CI (1.11, 3.61)], varenicline plus nicotine replacement therapy over nicotine replacement therapy [OR = 1.84, 95% CI (1.07, 3.18)], and nicotine replacement therapy plus mecamylamine over naltrexone [OR = 6.29, 95% CI (1.59, 24.90)]. Finally, the surface under the cumulative ranking curve value indicated that nicotine replacement therapy plus mecamylamine had the greatest probability of becoming the best intervention.Conclusion: Most pharmacological interventions demonstrated a benefit in smoking cessation compared with placebo, whether monotherapy or combination therapy. Moreover, confirmed evidence suggested that some combination treatments, such as varenicline plus bupropion and nicotine replacement therapy plus mecamylamine have a higher probability of being the best smoking cessation inhttps://www.frontiersin.org/articles/10.3389/fphar.2022.1012433/fullpharmacotherapysmoking cessationSystematic reviewnetwork meta-analysistobacco |
| spellingShingle | Xue Shang Xue Shang Xue Shang Kangle Guo Kangle Guo Kangle Guo Fenfen E. Fenfen E. Fenfen E. Xinxin Deng Xinxin Deng Xinxin Deng Yongsheng Wang Yongsheng Wang Yongsheng Wang Ziyi Wang Ziyi Wang Ziyi Wang Yanan Wu Yanan Wu Yanan Wu Meng Xu Meng Xu Meng Xu Chaoqun Yang Chaoqun Yang Chaoqun Yang Xiuxia Li Xiuxia Li Xiuxia Li Kehu Yang Kehu Yang Kehu Yang Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis Frontiers in Pharmacology pharmacotherapy smoking cessation Systematic review network meta-analysis tobacco |
| title | Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis |
| title_full | Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis |
| title_fullStr | Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis |
| title_full_unstemmed | Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis |
| title_short | Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis |
| title_sort | pharmacological interventions on smoking cessation a systematic review and network meta analysis |
| topic | pharmacotherapy smoking cessation Systematic review network meta-analysis tobacco |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1012433/full |
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