Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

Abstract Background The adaptive immune response intrinsically depends on hypervariable human leukocyte antigen (HLA) genes. Concomitantly, correct HLA phenotyping is crucial for successful donor-patient matching in organ transplantation. The cost and technical limitations of current laboratory tech...

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Bibliographic Details
Main Authors: Maria Luisa Matey-Hernandez, Danish Pan Genome Consortium, Søren Brunak, Jose M. G. Izarzugaza
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Bioinformatics
Subjects:
HLA genotyping
NGS
Clinical genomics
Population genetics
Prediction
Online Access:http://link.springer.com/article/10.1186/s12859-018-2239-6

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