Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep
Abstract Background Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variabili...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-017-1170-9 |
| _version_ | 1819120198189318144 |
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| author | José A. Camassa Camila C. Diogo João P. A. Bordelo Marília de A. Bonelli Carlos A. Viegas Jorge T. Azevedo Nuno Dourado Isabel R. Dias |
| author_facet | José A. Camassa Camila C. Diogo João P. A. Bordelo Marília de A. Bonelli Carlos A. Viegas Jorge T. Azevedo Nuno Dourado Isabel R. Dias |
| author_sort | José A. Camassa |
| collection | DOAJ |
| description | Abstract Background Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it is important to have as much data published on the subject as possible. The aim of this study was therefore to generate a reference range for alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) and validate the already published data. Results Serum alkaline phosphatase decreased with age, with statistical difference between the 1 month old and the other groups and between the over 8 years and the 6 months old groups. There was also a statistical difference in the ALP levels between the 3 to 5 years old gestation and lactation groups. For serum tartrate-resistant acid phosphatase, there was a statistical difference mainly between the 1 month old and the 6 months old, 6–8 years old, and above 8 years old groups. Conclusions The results obtained could represent a useful tool for future studies using sheep as an animal model for orthopedic research. The different groups presented a wide variation of serum ALP and TRAP levels, however, these variations are entirely explained by known physiology. Therefore, this detailed study confirms the prediction that unexplained changes in these bone turnover markers do not occur during the lifespan of sheep. |
| first_indexed | 2024-12-22T06:16:51Z |
| format | Article |
| id | doaj.art-091d96765ccf4aa3b7fe35d8c4c3ab91 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-22T06:16:51Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-091d96765ccf4aa3b7fe35d8c4c3ab912022-12-21T18:36:04ZengBMCBMC Veterinary Research1746-61482017-08-011311810.1186/s12917-017-1170-9Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheepJosé A. Camassa0Camila C. Diogo1João P. A. Bordelo2Marília de A. Bonelli3Carlos A. Viegas4Jorge T. Azevedo5Nuno Dourado6Isabel R. Dias7Department of Veterinary Sciences, Agricultural and Veterinary Sciences School (ECAV), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de PradosDepartment of Veterinary Sciences, Agricultural and Veterinary Sciences School (ECAV), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de PradosDepartment of Veterinary Sciences, Agricultural and Veterinary Sciences School (ECAV), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de PradosFederal Rural University of Pernambuco (UFRPE), R. Dom Manoel de Medeiros, s/n, Dois IrmãosDepartment of Veterinary Sciences, Agricultural and Veterinary Sciences School (ECAV), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de PradosDepartment of Animal Sciences, ECAV, UTADCMEMS-UMinho, Department of Mechanical Engineering, University of Minho, Campus de AzurémDepartment of Veterinary Sciences, Agricultural and Veterinary Sciences School (ECAV), University of Trás-os-Montes and Alto Douro (UTAD), Quinta de PradosAbstract Background Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it is important to have as much data published on the subject as possible. The aim of this study was therefore to generate a reference range for alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) and validate the already published data. Results Serum alkaline phosphatase decreased with age, with statistical difference between the 1 month old and the other groups and between the over 8 years and the 6 months old groups. There was also a statistical difference in the ALP levels between the 3 to 5 years old gestation and lactation groups. For serum tartrate-resistant acid phosphatase, there was a statistical difference mainly between the 1 month old and the 6 months old, 6–8 years old, and above 8 years old groups. Conclusions The results obtained could represent a useful tool for future studies using sheep as an animal model for orthopedic research. The different groups presented a wide variation of serum ALP and TRAP levels, however, these variations are entirely explained by known physiology. Therefore, this detailed study confirms the prediction that unexplained changes in these bone turnover markers do not occur during the lifespan of sheep.http://link.springer.com/article/10.1186/s12917-017-1170-9ALPBone tissueSerum mineralsSheepTartrate-resistant acid phosphatase |
| spellingShingle | José A. Camassa Camila C. Diogo João P. A. Bordelo Marília de A. Bonelli Carlos A. Viegas Jorge T. Azevedo Nuno Dourado Isabel R. Dias Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep BMC Veterinary Research ALP Bone tissue Serum minerals Sheep Tartrate-resistant acid phosphatase |
| title | Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep |
| title_full | Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep |
| title_fullStr | Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep |
| title_full_unstemmed | Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep |
| title_short | Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep |
| title_sort | tartrate resistant acid phosphate as biomarker of bone turnover over the lifespan and different physiologic stages in sheep |
| topic | ALP Bone tissue Serum minerals Sheep Tartrate-resistant acid phosphatase |
| url | http://link.springer.com/article/10.1186/s12917-017-1170-9 |
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