Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion
Abstract Background The aim of the study was to investigate the changes in the periarterial capillary-free zone (paCFZ) after anti-vascular endothelial growth factor (VEGF) therapy in patients with branch retinal vein occlusion (BRVO) by wide-field swept-source optical coherence tomography angiograp...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | Eye and Vision |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40662-022-00297-z |
| _version_ | 1818533878490464256 |
|---|---|
| author | Wenyi Tang Wei Liu Jingli Guo Lili Zhang Gezhi Xu Keyan Wang Qing Chang |
| author_facet | Wenyi Tang Wei Liu Jingli Guo Lili Zhang Gezhi Xu Keyan Wang Qing Chang |
| author_sort | Wenyi Tang |
| collection | DOAJ |
| description | Abstract Background The aim of the study was to investigate the changes in the periarterial capillary-free zone (paCFZ) after anti-vascular endothelial growth factor (VEGF) therapy in patients with branch retinal vein occlusion (BRVO) by wide-field swept-source optical coherence tomography angiography (SS-OCTA) and assess their associations with clinical outcomes. Methods In this retrospective observational study of 54 treatment-naïve BRVO patients with macular edema, we reviewed the findings of 12 × 12 mm2 SS-OCTA at baseline, 3, 6, and 12 months after intravitreal ranibizumab injections. The paCFZ and major retinal artery areas were measured on SS-OCTA images. The paCFZ area to artery area (P/A) ratio was calculated. Results The paCFZ areas and P/A ratios of first- and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes (all P < 0.01), but there were no differences in the first- and second-order artery areas (P = 0.20 and 0.25, respectively). The paCFZ areas and P/A ratios decreased significantly at 3, 6, and 12 months after anti-VEGF therapy (all P < 0.01). The baseline P/A ratio was significantly correlated with the baseline best-corrected visual acuity (BCVA), central retinal thickness, and their improvements at 3, 6, and 12 months (all P < 0.05). Baseline BCVA and P/A ratios of first- and second-order arteries were independently associated with the final BCVA in multivariate linear regression. Conclusions Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in BRVO. Smaller baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy. |
| first_indexed | 2024-12-11T18:04:32Z |
| format | Article |
| id | doaj.art-09215d3ef4ec4bc1b6067b959c400914 |
| institution | Directory Open Access Journal |
| issn | 2326-0254 |
| language | English |
| last_indexed | 2024-12-11T18:04:32Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj.art-09215d3ef4ec4bc1b6067b959c4009142022-12-22T00:55:46ZengBMCEye and Vision2326-02542022-07-019111010.1186/s40662-022-00297-zWide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusionWenyi Tang0Wei Liu1Jingli Guo2Lili Zhang3Gezhi Xu4Keyan Wang5Qing Chang6Department of Ophthalmology, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology, Eye and ENT Hospital of Fudan UniversityAbstract Background The aim of the study was to investigate the changes in the periarterial capillary-free zone (paCFZ) after anti-vascular endothelial growth factor (VEGF) therapy in patients with branch retinal vein occlusion (BRVO) by wide-field swept-source optical coherence tomography angiography (SS-OCTA) and assess their associations with clinical outcomes. Methods In this retrospective observational study of 54 treatment-naïve BRVO patients with macular edema, we reviewed the findings of 12 × 12 mm2 SS-OCTA at baseline, 3, 6, and 12 months after intravitreal ranibizumab injections. The paCFZ and major retinal artery areas were measured on SS-OCTA images. The paCFZ area to artery area (P/A) ratio was calculated. Results The paCFZ areas and P/A ratios of first- and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes (all P < 0.01), but there were no differences in the first- and second-order artery areas (P = 0.20 and 0.25, respectively). The paCFZ areas and P/A ratios decreased significantly at 3, 6, and 12 months after anti-VEGF therapy (all P < 0.01). The baseline P/A ratio was significantly correlated with the baseline best-corrected visual acuity (BCVA), central retinal thickness, and their improvements at 3, 6, and 12 months (all P < 0.05). Baseline BCVA and P/A ratios of first- and second-order arteries were independently associated with the final BCVA in multivariate linear regression. Conclusions Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in BRVO. Smaller baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy.https://doi.org/10.1186/s40662-022-00297-zSwept-source optical coherence tomography angiographyBranch retinal vein occlusionPeriarterial capillary free zoneAnti-VEGF treatmentPrognosis |
| spellingShingle | Wenyi Tang Wei Liu Jingli Guo Lili Zhang Gezhi Xu Keyan Wang Qing Chang Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion Eye and Vision Swept-source optical coherence tomography angiography Branch retinal vein occlusion Periarterial capillary free zone Anti-VEGF treatment Prognosis |
| title | Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion |
| title_full | Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion |
| title_fullStr | Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion |
| title_full_unstemmed | Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion |
| title_short | Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion |
| title_sort | wide field swept source oct angiography of the periarterial capillary free zone before and after anti vegf therapy for branch retinal vein occlusion |
| topic | Swept-source optical coherence tomography angiography Branch retinal vein occlusion Periarterial capillary free zone Anti-VEGF treatment Prognosis |
| url | https://doi.org/10.1186/s40662-022-00297-z |
| work_keys_str_mv | AT wenyitang widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion AT weiliu widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion AT jingliguo widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion AT lilizhang widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion AT gezhixu widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion AT keyanwang widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion AT qingchang widefieldsweptsourceoctangiographyoftheperiarterialcapillaryfreezonebeforeandafterantivegftherapyforbranchretinalveinocclusion |