Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study
Background: Birth is a traumatic event with molding forces directed to the fetal skull, which may result in intracranial hemorrhages. However, the knowledge on prevalence and risk factors of incidental brain magnetic resonance imaging (MRI) findings in infants is still inconclusive.Methods: The prev...
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01347/full |
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| author | Venla Kumpulainen Satu J. Lehtola Jetro J. Tuulari Jetro J. Tuulari Eero Silver Anni Copeland Riikka Korja Riikka Korja Hasse Karlsson Hasse Karlsson Hasse Karlsson Linnea Karlsson Linnea Karlsson Linnea Karlsson Harri Merisaari Harri Merisaari Harri Merisaari Riitta Parkkola Riitta Parkkola Jani Saunavaara Tuire Lähdesmäki Tuire Lähdesmäki Noora M. Scheinin Noora M. Scheinin |
| author_facet | Venla Kumpulainen Satu J. Lehtola Jetro J. Tuulari Jetro J. Tuulari Eero Silver Anni Copeland Riikka Korja Riikka Korja Hasse Karlsson Hasse Karlsson Hasse Karlsson Linnea Karlsson Linnea Karlsson Linnea Karlsson Harri Merisaari Harri Merisaari Harri Merisaari Riitta Parkkola Riitta Parkkola Jani Saunavaara Tuire Lähdesmäki Tuire Lähdesmäki Noora M. Scheinin Noora M. Scheinin |
| author_sort | Venla Kumpulainen |
| collection | DOAJ |
| description | Background: Birth is a traumatic event with molding forces directed to the fetal skull, which may result in intracranial hemorrhages. However, the knowledge on prevalence and risk factors of incidental brain magnetic resonance imaging (MRI) findings in infants is still inconclusive.Methods: The prevalence and nature of incidental MRI findings were assessed in a birth cohort of 175 asymptomatic infants. The role of delivery method as well as other potential risk factors for intracranial hemorrhages were evaluated. The infants underwent 3T MRI at the age of 2–5 weeks, and the neurological status of the infants with an incidental finding was evaluated by a pediatric neurologist. Information on the delivery method, duration of delivery, parity, used anesthesia, oxytocin induction, and Apgar score was gathered to evaluate their association with the prevalence of hemorrhages.Results: Incidental intracranial hemorrhages were detected in 12 infants (6.9%), all following spontaneous or assisted vaginal delivery. Vacuum-assistance was found to be a risk factor for subdural hemorrhages with an odds ratio (OR) of 4.7 (95% CI [1.18; 18.9], p = 0.032). All infants were evaluated to develop normally by their clinical status.Conclusions: Incidental intracranial hemorrhages are relatively common among infants born by vaginal delivery. They are often of little clinical significance within the first years of life and have unlikely consequences for later neurodevelopment either. Despite their benign character, investigators should be prepared to share this information with parents competently as the findings can cause parental anxiety, and especially as the popularity of MRI as a research tool is increasing. |
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| last_indexed | 2024-12-21T22:51:20Z |
| publishDate | 2020-01-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-09216c50d99542888363f1c7a4102cb42022-12-21T18:47:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-01-011010.3389/fneur.2019.01347503057Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort StudyVenla Kumpulainen0Satu J. Lehtola1Jetro J. Tuulari2Jetro J. Tuulari3Eero Silver4Anni Copeland5Riikka Korja6Riikka Korja7Hasse Karlsson8Hasse Karlsson9Hasse Karlsson10Linnea Karlsson11Linnea Karlsson12Linnea Karlsson13Harri Merisaari14Harri Merisaari15Harri Merisaari16Riitta Parkkola17Riitta Parkkola18Jani Saunavaara19Tuire Lähdesmäki20Tuire Lähdesmäki21Noora M. Scheinin22Noora M. Scheinin23FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandDepartment of Psychiatry, Turku University Hospital, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandDepartment of Psychology, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandDepartment of Psychiatry, Turku University Hospital, University of Turku, Turku, FinlandCentre for Population Health Research, Turku University Hospital, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandCentre for Population Health Research, Turku University Hospital, University of Turku, Turku, FinlandDepartment of Child Psychiatry, Turku University Hospital, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandDepartment of Future Technologies, University of Turku, Turku, FinlandCenter of Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, OH, United StatesFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandDepartment of Radiology, Turku University Hospital, University of Turku, Turku, FinlandDepartment of Medical Physics, Turku University Hospital, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland0Department of Pediatric Neurology, Turku University Hospital, University of Turku, Turku, FinlandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, FinlandDepartment of Psychiatry, Turku University Hospital, University of Turku, Turku, FinlandBackground: Birth is a traumatic event with molding forces directed to the fetal skull, which may result in intracranial hemorrhages. However, the knowledge on prevalence and risk factors of incidental brain magnetic resonance imaging (MRI) findings in infants is still inconclusive.Methods: The prevalence and nature of incidental MRI findings were assessed in a birth cohort of 175 asymptomatic infants. The role of delivery method as well as other potential risk factors for intracranial hemorrhages were evaluated. The infants underwent 3T MRI at the age of 2–5 weeks, and the neurological status of the infants with an incidental finding was evaluated by a pediatric neurologist. Information on the delivery method, duration of delivery, parity, used anesthesia, oxytocin induction, and Apgar score was gathered to evaluate their association with the prevalence of hemorrhages.Results: Incidental intracranial hemorrhages were detected in 12 infants (6.9%), all following spontaneous or assisted vaginal delivery. Vacuum-assistance was found to be a risk factor for subdural hemorrhages with an odds ratio (OR) of 4.7 (95% CI [1.18; 18.9], p = 0.032). All infants were evaluated to develop normally by their clinical status.Conclusions: Incidental intracranial hemorrhages are relatively common among infants born by vaginal delivery. They are often of little clinical significance within the first years of life and have unlikely consequences for later neurodevelopment either. Despite their benign character, investigators should be prepared to share this information with parents competently as the findings can cause parental anxiety, and especially as the popularity of MRI as a research tool is increasing.https://www.frontiersin.org/article/10.3389/fneur.2019.01347/fullinfantincidental findingMRIsubdural hemorrhagedelivery method |
| spellingShingle | Venla Kumpulainen Satu J. Lehtola Jetro J. Tuulari Jetro J. Tuulari Eero Silver Anni Copeland Riikka Korja Riikka Korja Hasse Karlsson Hasse Karlsson Hasse Karlsson Linnea Karlsson Linnea Karlsson Linnea Karlsson Harri Merisaari Harri Merisaari Harri Merisaari Riitta Parkkola Riitta Parkkola Jani Saunavaara Tuire Lähdesmäki Tuire Lähdesmäki Noora M. Scheinin Noora M. Scheinin Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study Frontiers in Neurology infant incidental finding MRI subdural hemorrhage delivery method |
| title | Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study |
| title_full | Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study |
| title_fullStr | Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study |
| title_full_unstemmed | Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study |
| title_short | Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates—The FinnBrain Birth Cohort Study |
| title_sort | prevalence and risk factors of incidental findings in brain mris of healthy neonates the finnbrain birth cohort study |
| topic | infant incidental finding MRI subdural hemorrhage delivery method |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01347/full |
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