Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential
Titanium based materials have been widely applied in bone-tissue engineering. However, inefficient bone repair remains to be solved due to the lack of neural network reconstruction at the bone-implant interface. Herein, we propose a functional surface modification approach to promote neurogenesis. U...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.839093/full |
| _version_ | 1828136542097375232 |
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| author | Hang Zhao Feng Liu Yixin Yin Shuhua Wang |
| author_facet | Hang Zhao Feng Liu Yixin Yin Shuhua Wang |
| author_sort | Hang Zhao |
| collection | DOAJ |
| description | Titanium based materials have been widely applied in bone-tissue engineering. However, inefficient bone repair remains to be solved due to the lack of neural network reconstruction at the bone-implant interface. Herein, we propose a functional surface modification approach to promote neurogenesis. Using an electrochemical technique and a hydrothermal approach, a potassium titanate nanorod-decorated titanium oxide (K2Ti6O13-TiO2) nanotube array is constructed on the surface of titanium implants. The K2Ti6O13-TiO2 hybrid nanotube array on titanium implants can enhance the osteogenic differentiation of mesenchymal stem cells due to the special nanostructures of titanium oxide nanorods. Meanwhile, the release of potassium ions is able to accelerate the neural differentiation of neural stem cells. This study provides a new approach to promote neuralization on the surface of implants, which is promising for future applications in constructing a fully functional interface in bone repair. |
| first_indexed | 2024-04-11T18:06:01Z |
| format | Article |
| id | doaj.art-0923adaebd87454fa9270a58348240f1 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T18:06:01Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-0923adaebd87454fa9270a58348240f12022-12-22T04:10:19ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-01-011010.3389/fchem.2022.839093839093Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation PotentialHang Zhao0Feng Liu1Yixin Yin2Shuhua Wang3State Key Laboratory of Crystal Materials, Shandong University, Jinan, ChinaState Key Laboratory of Crystal Materials, Shandong University, Jinan, ChinaOral Implantology Center, Jinan Stomatological Hospital, Jinan, ChinaState Key Laboratory of Crystal Materials, Shandong University, Jinan, ChinaTitanium based materials have been widely applied in bone-tissue engineering. However, inefficient bone repair remains to be solved due to the lack of neural network reconstruction at the bone-implant interface. Herein, we propose a functional surface modification approach to promote neurogenesis. Using an electrochemical technique and a hydrothermal approach, a potassium titanate nanorod-decorated titanium oxide (K2Ti6O13-TiO2) nanotube array is constructed on the surface of titanium implants. The K2Ti6O13-TiO2 hybrid nanotube array on titanium implants can enhance the osteogenic differentiation of mesenchymal stem cells due to the special nanostructures of titanium oxide nanorods. Meanwhile, the release of potassium ions is able to accelerate the neural differentiation of neural stem cells. This study provides a new approach to promote neuralization on the surface of implants, which is promising for future applications in constructing a fully functional interface in bone repair.https://www.frontiersin.org/articles/10.3389/fchem.2022.839093/fullpotassiumTiO2 surfacesosteogenesisneurogenesisfully functional interface |
| spellingShingle | Hang Zhao Feng Liu Yixin Yin Shuhua Wang Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential Frontiers in Chemistry potassium TiO2 surfaces osteogenesis neurogenesis fully functional interface |
| title | Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential |
| title_full | Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential |
| title_fullStr | Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential |
| title_full_unstemmed | Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential |
| title_short | Potassium Titanate Assembled Titanium Dioxide Nanotube Arrays Endow Titanium Implants Excellent Osseointegration Performance and Nerve Formation Potential |
| title_sort | potassium titanate assembled titanium dioxide nanotube arrays endow titanium implants excellent osseointegration performance and nerve formation potential |
| topic | potassium TiO2 surfaces osteogenesis neurogenesis fully functional interface |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.839093/full |
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