Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy
Objectives The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we use...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Yong Chan Lee
2023-12-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://helicojournal.org/upload/pdf/kjhugr-2023-0042.pdf |
| _version_ | 1797387641580158976 |
|---|---|
| author | Yuri Kim Ji Yong Ahn Hwoon-Yong Jung Jin Hee Noh Hee Kyong Na Kee Wook Jung Jeong Hoon Lee Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee |
| author_facet | Yuri Kim Ji Yong Ahn Hwoon-Yong Jung Jin Hee Noh Hee Kyong Na Kee Wook Jung Jeong Hoon Lee Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee |
| author_sort | Yuri Kim |
| collection | DOAJ |
| description | Objectives The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we used a chronological cohort dataset to conduct a comparative analysis of the eradication rates, compliance, and adverse events associated with the 7-day STT and SQ. Methods A total of 789 patients underwent HPE treatment at Asan Medical Center between July 2013 and August 2017. Among them, 378 received a 7-day STT and 411 received a 10-day SQ. Baseline clinical data and treatment parameters were compared between the two treatment groups. Results SQ demonstrated an eradication rate of 84.7% (348/411), which was superior to that of the 7-day STT (74.1%; p<0.001). The incidence of adverse events was also higher in the SQ group than in the STT group (17.5% vs. 11.1%; p=0.01). Nonetheless, treatment compliance was not significantly different between the groups (98.1% [SQ] vs. 96.8% [STT]; p=0.38). Among the patients undergoing second-line eradication, the SQ group displayed a lower eradication rate than the STT group (77.8% vs. 92.4%; p=0.028). Notably, the overall eradication rate did not differ significantly between the two groups (98.3% [STT] vs. 97.4% [SQ]; p=0.56). Conclusions SQ exhibited superior efficacy compared with the 7-day STT as a first-line H. pylori treatment. Thus, SQ holds potential to serve as the replacement for the 7-day STT in treatment-naïve patients. |
| first_indexed | 2024-03-08T22:28:57Z |
| format | Article |
| id | doaj.art-0923bab70c69476aa4a527dc6e84c51f |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-03-08T22:28:57Z |
| publishDate | 2023-12-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-0923bab70c69476aa4a527dc6e84c51f2023-12-18T07:11:45ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312023-12-0123427728210.7704/kjhugr.2023.0042805Comparison of Eradication Rates Using Standard Triple Therapy and Sequential TherapyYuri Kim0Ji Yong Ahn1Hwoon-Yong JungJin Hee Noh2Hee Kyong Na3Kee Wook Jung4Jeong Hoon Lee5Do Hoon Kim6Kee Don Choi7Ho June Song8Gin Hyug Lee9 Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, KoreaObjectives The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we used a chronological cohort dataset to conduct a comparative analysis of the eradication rates, compliance, and adverse events associated with the 7-day STT and SQ. Methods A total of 789 patients underwent HPE treatment at Asan Medical Center between July 2013 and August 2017. Among them, 378 received a 7-day STT and 411 received a 10-day SQ. Baseline clinical data and treatment parameters were compared between the two treatment groups. Results SQ demonstrated an eradication rate of 84.7% (348/411), which was superior to that of the 7-day STT (74.1%; p<0.001). The incidence of adverse events was also higher in the SQ group than in the STT group (17.5% vs. 11.1%; p=0.01). Nonetheless, treatment compliance was not significantly different between the groups (98.1% [SQ] vs. 96.8% [STT]; p=0.38). Among the patients undergoing second-line eradication, the SQ group displayed a lower eradication rate than the STT group (77.8% vs. 92.4%; p=0.028). Notably, the overall eradication rate did not differ significantly between the two groups (98.3% [STT] vs. 97.4% [SQ]; p=0.56). Conclusions SQ exhibited superior efficacy compared with the 7-day STT as a first-line H. pylori treatment. Thus, SQ holds potential to serve as the replacement for the 7-day STT in treatment-naïve patients.http://helicojournal.org/upload/pdf/kjhugr-2023-0042.pdf eradicationantibioticsstandard triple therapysequential therapy |
| spellingShingle | Yuri Kim Ji Yong Ahn Hwoon-Yong Jung Jin Hee Noh Hee Kyong Na Kee Wook Jung Jeong Hoon Lee Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy The Korean Journal of Helicobacter and Upper Gastrointestinal Research eradication antibiotics standard triple therapy sequential therapy |
| title | Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy |
| title_full | Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy |
| title_fullStr | Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy |
| title_full_unstemmed | Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy |
| title_short | Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy |
| title_sort | comparison of eradication rates using standard triple therapy and sequential therapy |
| topic | eradication antibiotics standard triple therapy sequential therapy |
| url | http://helicojournal.org/upload/pdf/kjhugr-2023-0042.pdf |
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