Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder
Abstract Background It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This study is to investigate the alterations in the resting-state functional con...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12868-017-0375-y |
| _version_ | 1819211452201828352 |
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| author | Xin Ge Yawen Sun Xu Han Yao Wang Weina Ding Mengqiu Cao Yasong Du Jianrong Xu Yan Zhou |
| author_facet | Xin Ge Yawen Sun Xu Han Yao Wang Weina Ding Mengqiu Cao Yasong Du Jianrong Xu Yan Zhou |
| author_sort | Xin Ge |
| collection | DOAJ |
| description | Abstract Background It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This study is to investigate the alterations in the resting-state functional connectivity (rsFC) of the dorsolateral prefrontal cortex (DLPFC) observed in SND and IGD. In this study, 27 IGD, 29 SND, and 33 healthy controls (HC) underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. DLPFC connectivity was determined in all participates by investigating the synchronized low-frequency fMRI signal fluctuations using a temporal seed-based correlation method. Results Compared with the HC group, the IGD and SND groups showed decreased rsFC with DLPFC in the right insula and left inferior frontal gyrus with DLPFC. Compared with SND group, the IGD subjects exhibited increased rsFC in the left inferior temporal gyrus and right inferior orbital frontal gyrus and decreased rsFC in the right middle occipital gyrus, supramarginal gyrus, and cuneus with DLPFC. Conclusion Our results confirmed that SND and IGD share similar neural mechanisms related to craving and impulsive inhibitions. The significant difference in rsFC with DLPFC between the IGD and SND subjects may be attributed to the visual and auditory stimulation generated by long-term internet gaming. |
| first_indexed | 2024-12-23T06:27:18Z |
| format | Article |
| id | doaj.art-09248d0b468a421f8ec3e741629398e5 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-23T06:27:18Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-09248d0b468a421f8ec3e741629398e52022-12-21T17:57:01ZengBMCBMC Neuroscience1471-22022017-07-0118111010.1186/s12868-017-0375-yDifference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorderXin Ge0Yawen Sun1Xu Han2Yao Wang3Weina Ding4Mengqiu Cao5Yasong Du6Jianrong Xu7Yan Zhou8Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Child & Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract Background It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This study is to investigate the alterations in the resting-state functional connectivity (rsFC) of the dorsolateral prefrontal cortex (DLPFC) observed in SND and IGD. In this study, 27 IGD, 29 SND, and 33 healthy controls (HC) underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. DLPFC connectivity was determined in all participates by investigating the synchronized low-frequency fMRI signal fluctuations using a temporal seed-based correlation method. Results Compared with the HC group, the IGD and SND groups showed decreased rsFC with DLPFC in the right insula and left inferior frontal gyrus with DLPFC. Compared with SND group, the IGD subjects exhibited increased rsFC in the left inferior temporal gyrus and right inferior orbital frontal gyrus and decreased rsFC in the right middle occipital gyrus, supramarginal gyrus, and cuneus with DLPFC. Conclusion Our results confirmed that SND and IGD share similar neural mechanisms related to craving and impulsive inhibitions. The significant difference in rsFC with DLPFC between the IGD and SND subjects may be attributed to the visual and auditory stimulation generated by long-term internet gaming.http://link.springer.com/article/10.1186/s12868-017-0375-yFunctional magnetic resonance imagingInternet gaming disorderNicotine dependenceResting-state functional connectivityDorsolateral prefrontal cortex |
| spellingShingle | Xin Ge Yawen Sun Xu Han Yao Wang Weina Ding Mengqiu Cao Yasong Du Jianrong Xu Yan Zhou Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder BMC Neuroscience Functional magnetic resonance imaging Internet gaming disorder Nicotine dependence Resting-state functional connectivity Dorsolateral prefrontal cortex |
| title | Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder |
| title_full | Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder |
| title_fullStr | Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder |
| title_full_unstemmed | Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder |
| title_short | Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder |
| title_sort | difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder |
| topic | Functional magnetic resonance imaging Internet gaming disorder Nicotine dependence Resting-state functional connectivity Dorsolateral prefrontal cortex |
| url | http://link.springer.com/article/10.1186/s12868-017-0375-y |
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