Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode
An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide–TiO2–Au nanocomposite-modified glassy carbon electrode (rGO–TiO2–Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to conf...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.892919/full |
| _version_ | 1818270989398573056 |
|---|---|
| author | Xin-Yang Lu Jing Li Fen-Ying Kong Mei-Jie Wei Pei Zhang Ying Li Hai-Lin Fang Wei Wang |
| author_facet | Xin-Yang Lu Jing Li Fen-Ying Kong Mei-Jie Wei Pei Zhang Ying Li Hai-Lin Fang Wei Wang |
| author_sort | Xin-Yang Lu |
| collection | DOAJ |
| description | An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide–TiO2–Au nanocomposite-modified glassy carbon electrode (rGO–TiO2–Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO–TiO2–Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO–TiO2–Au/GCE for ACV. As a result, rGO–TiO2–Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1–100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results. |
| first_indexed | 2024-12-12T21:19:02Z |
| format | Article |
| id | doaj.art-0925900344aa4ec980d1d60610b7b9e9 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-12T21:19:02Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-0925900344aa4ec980d1d60610b7b9e92022-12-22T00:11:39ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-05-011010.3389/fchem.2022.892919892919Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified ElectrodeXin-Yang LuJing LiFen-Ying KongMei-Jie WeiPei ZhangYing LiHai-Lin FangWei WangAn electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide–TiO2–Au nanocomposite-modified glassy carbon electrode (rGO–TiO2–Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO–TiO2–Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO–TiO2–Au/GCE for ACV. As a result, rGO–TiO2–Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1–100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.https://www.frontiersin.org/articles/10.3389/fchem.2022.892919/fullacyclovirelectrochemical sensorchemically modified electrodemetallic oxidereduced graphene oxide |
| spellingShingle | Xin-Yang Lu Jing Li Fen-Ying Kong Mei-Jie Wei Pei Zhang Ying Li Hai-Lin Fang Wei Wang Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode Frontiers in Chemistry acyclovir electrochemical sensor chemically modified electrode metallic oxide reduced graphene oxide |
| title | Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode |
| title_full | Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode |
| title_fullStr | Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode |
| title_full_unstemmed | Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode |
| title_short | Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode |
| title_sort | improved performance for the electrochemical sensing of acyclovir by using the rgo tio2 au nanocomposite modified electrode |
| topic | acyclovir electrochemical sensor chemically modified electrode metallic oxide reduced graphene oxide |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.892919/full |
| work_keys_str_mv | AT xinyanglu improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT jingli improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT fenyingkong improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT meijiewei improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT peizhang improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT yingli improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT hailinfang improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode AT weiwang improvedperformancefortheelectrochemicalsensingofacyclovirbyusingthergotio2aunanocompositemodifiedelectrode |