Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections
Summary: Siglecs are a family of emerging glyco-immune checkpoints. Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialoglycan interactions play an important role in modu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396422005369 |
| _version_ | 1828335666069504000 |
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| author | Pratima Saini Opeyemi S. Adeniji Mohamed Abdel-Mohsen |
| author_facet | Pratima Saini Opeyemi S. Adeniji Mohamed Abdel-Mohsen |
| author_sort | Pratima Saini |
| collection | DOAJ |
| description | Summary: Siglecs are a family of emerging glyco-immune checkpoints. Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialoglycan interactions play an important role in modulating immunological functions during cancer, however, their roles in regulating immunological equilibrium during viral infections is less clear. In this review, we discuss the documented and potential roles of inhibitory Siglecs in balancing immune activation and tolerance during viral infections and consider how this balance could affect both the desired anti-viral immunological functions and the unwanted hyper- or chronic inflammation. Finally, we discuss the opportunities to target the Siglec immunological switches to reach an immunological balance during viral infections: inhibiting specific Siglec-sialoglycan interactions when maximum anti-viral immune responses are needed, or inducing other interactions when preventing excessive inflammation or reducing chronic immune activation are the goals. |
| first_indexed | 2024-04-13T21:50:36Z |
| format | Article |
| id | doaj.art-0925d9ecf0974676ba6101e034387f5e |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-04-13T21:50:36Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-0925d9ecf0974676ba6101e034387f5e2022-12-22T02:28:25ZengElsevierEBioMedicine2352-39642022-12-0186104354Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infectionsPratima Saini0Opeyemi S. Adeniji1Mohamed Abdel-Mohsen2The Wistar Institute, Philadelphia, PA, 19104, USAThe Wistar Institute, Philadelphia, PA, 19104, USACorresponding author. Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.; The Wistar Institute, Philadelphia, PA, 19104, USASummary: Siglecs are a family of emerging glyco-immune checkpoints. Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialoglycan interactions play an important role in modulating immunological functions during cancer, however, their roles in regulating immunological equilibrium during viral infections is less clear. In this review, we discuss the documented and potential roles of inhibitory Siglecs in balancing immune activation and tolerance during viral infections and consider how this balance could affect both the desired anti-viral immunological functions and the unwanted hyper- or chronic inflammation. Finally, we discuss the opportunities to target the Siglec immunological switches to reach an immunological balance during viral infections: inhibiting specific Siglec-sialoglycan interactions when maximum anti-viral immune responses are needed, or inducing other interactions when preventing excessive inflammation or reducing chronic immune activation are the goals.http://www.sciencedirect.com/science/article/pii/S2352396422005369Viral infectionsSiglecSialic acidImmune activationImmune toleranceImmune surveillance |
| spellingShingle | Pratima Saini Opeyemi S. Adeniji Mohamed Abdel-Mohsen Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections EBioMedicine Viral infections Siglec Sialic acid Immune activation Immune tolerance Immune surveillance |
| title | Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections |
| title_full | Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections |
| title_fullStr | Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections |
| title_full_unstemmed | Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections |
| title_short | Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections |
| title_sort | inhibitory siglec sialic acid interactions in balancing immunological activation and tolerance during viral infections |
| topic | Viral infections Siglec Sialic acid Immune activation Immune tolerance Immune surveillance |
| url | http://www.sciencedirect.com/science/article/pii/S2352396422005369 |
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