Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections

Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections

Summary: Siglecs are a family of emerging glyco-immune checkpoints. Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialoglycan interactions play an important role in modu...

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Bibliographic Details
Main Authors:	Pratima Saini, Opeyemi S. Adeniji, Mohamed Abdel-Mohsen
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Series:	EBioMedicine
Subjects:	Viral infections Siglec Sialic acid Immune activation Immune tolerance Immune surveillance
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396422005369

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