Engineering of biomaterials for tumor modeling
Development of biomaterials mimicking tumor and its microenvironment has recently emerged for the use of drug discovery, precision medicine, and cancer biology. These biomimetic models have developed by reconstituting tumor and stroma cells within the 3D extracellular matrix. The models are recently...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Materials Today Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590049820300643 |
| _version_ | 1818601847650254848 |
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| author | S.R. Choi Y. Yang K.Y. Huang H.J. Kong M.J. Flick B. Han |
| author_facet | S.R. Choi Y. Yang K.Y. Huang H.J. Kong M.J. Flick B. Han |
| author_sort | S.R. Choi |
| collection | DOAJ |
| description | Development of biomaterials mimicking tumor and its microenvironment has recently emerged for the use of drug discovery, precision medicine, and cancer biology. These biomimetic models have developed by reconstituting tumor and stroma cells within the 3D extracellular matrix. The models are recently extended to recapitulate the in vivo tumor microenvironment, including biological, chemical, and mechanical conditions tailored for specific cancer type and its microenvironment. In spite of the recent emergence of various innovative engineered tumor models, many of these models are still early stage to be adapted for cancer research. In this article, we review the current status of biomaterials engineering for tumor models considering three main aspects—cellular engineering, matrix engineering, and engineering for microenvironmental conditions. Considering cancer-specific variability in these aspects, our discussion is focused on pancreatic cancer, specifically pancreatic ductal adenocarcinoma. In addition, we further discussed the current challenges and future opportunities to create reliable and relevant tumor models. |
| first_indexed | 2024-12-16T12:57:53Z |
| format | Article |
| id | doaj.art-0928743bfe504e309c4ce75650f9ffa0 |
| institution | Directory Open Access Journal |
| issn | 2590-0498 |
| language | English |
| last_indexed | 2024-12-16T12:57:53Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Advances |
| spelling | doaj.art-0928743bfe504e309c4ce75650f9ffa02022-12-21T22:30:58ZengElsevierMaterials Today Advances2590-04982020-12-018100117Engineering of biomaterials for tumor modelingS.R. Choi0Y. Yang1K.Y. Huang2H.J. Kong3M.J. Flick4B. Han5School of Mechanical Engineering, Purdue University, West Lafayette, IN, USADepartment of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, And Blood Research Center, University of North Carolina, Chapel Hill, NC, USADepartment of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USADepartment of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USADepartment of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, And Blood Research Center, University of North Carolina, Chapel Hill, NC, USASchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA; Weldon School of Biomedical Engineering and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN, USA; Corresponding author.Development of biomaterials mimicking tumor and its microenvironment has recently emerged for the use of drug discovery, precision medicine, and cancer biology. These biomimetic models have developed by reconstituting tumor and stroma cells within the 3D extracellular matrix. The models are recently extended to recapitulate the in vivo tumor microenvironment, including biological, chemical, and mechanical conditions tailored for specific cancer type and its microenvironment. In spite of the recent emergence of various innovative engineered tumor models, many of these models are still early stage to be adapted for cancer research. In this article, we review the current status of biomaterials engineering for tumor models considering three main aspects—cellular engineering, matrix engineering, and engineering for microenvironmental conditions. Considering cancer-specific variability in these aspects, our discussion is focused on pancreatic cancer, specifically pancreatic ductal adenocarcinoma. In addition, we further discussed the current challenges and future opportunities to create reliable and relevant tumor models.http://www.sciencedirect.com/science/article/pii/S2590049820300643BiomaterialsTumor modelCancer cellsExtracellular matrixTumor microenvironment |
| spellingShingle | S.R. Choi Y. Yang K.Y. Huang H.J. Kong M.J. Flick B. Han Engineering of biomaterials for tumor modeling Materials Today Advances Biomaterials Tumor model Cancer cells Extracellular matrix Tumor microenvironment |
| title | Engineering of biomaterials for tumor modeling |
| title_full | Engineering of biomaterials for tumor modeling |
| title_fullStr | Engineering of biomaterials for tumor modeling |
| title_full_unstemmed | Engineering of biomaterials for tumor modeling |
| title_short | Engineering of biomaterials for tumor modeling |
| title_sort | engineering of biomaterials for tumor modeling |
| topic | Biomaterials Tumor model Cancer cells Extracellular matrix Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2590049820300643 |
| work_keys_str_mv | AT srchoi engineeringofbiomaterialsfortumormodeling AT yyang engineeringofbiomaterialsfortumormodeling AT kyhuang engineeringofbiomaterialsfortumormodeling AT hjkong engineeringofbiomaterialsfortumormodeling AT mjflick engineeringofbiomaterialsfortumormodeling AT bhan engineeringofbiomaterialsfortumormodeling |