Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial
Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsul...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-01-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_11588_6fedfe9284a8f018f3379eb17ded2e1e.pdf |
| _version_ | 1818420455400275968 |
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| author | Reza Mohtashami Hasan Fallah huseini Farzaneh Nabati Reza Hajiaghaee Saeed Kianbakht |
| author_facet | Reza Mohtashami Hasan Fallah huseini Farzaneh Nabati Reza Hajiaghaee Saeed Kianbakht |
| author_sort | Reza Mohtashami |
| collection | DOAJ |
| description | Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. To evaluate the extract safety, serum SGOT, SGPT and creatinine levels were tested; also, the patients were requested to report any adverse effects. Results: FG, 2hPPG, HbA1c, TC, LDL-C, triglyceride and systolic and diastolic blood pressures were decreased, whereas HDL-C was increased significantly in the extract group compared to those of the placebo group at the endpoint (for all cases, p |
| first_indexed | 2024-12-14T12:54:44Z |
| format | Article |
| id | doaj.art-092a0439f1304682ad3f48d12c5b1293 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-14T12:54:44Z |
| publishDate | 2019-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-092a0439f1304682ad3f48d12c5b12932022-12-21T23:00:35ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492019-01-0191445310.22038/ajp.2018.1158811588Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trialReza Mohtashami0Hasan Fallah huseini1Farzaneh Nabati2Reza Hajiaghaee3Saeed Kianbakht4Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranMedicinal Plants Research Center, Institute of Medicinal Plants,ACECR, Karaj, Iran.Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.Institute of Medicinal Plants (ACECR)Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. To evaluate the extract safety, serum SGOT, SGPT and creatinine levels were tested; also, the patients were requested to report any adverse effects. Results: FG, 2hPPG, HbA1c, TC, LDL-C, triglyceride and systolic and diastolic blood pressures were decreased, whereas HDL-C was increased significantly in the extract group compared to those of the placebo group at the endpoint (for all cases, phttp://ajp.mums.ac.ir/article_11588_6fedfe9284a8f018f3379eb17ded2e1e.pdfVaccinium arctostaphylosHypertensionDiabetes MellitusDyslipidemia |
| spellingShingle | Reza Mohtashami Hasan Fallah huseini Farzaneh Nabati Reza Hajiaghaee Saeed Kianbakht Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial Avicenna Journal of Phytomedicine Vaccinium arctostaphylos Hypertension Diabetes Mellitus Dyslipidemia |
| title | Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_full | Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_fullStr | Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_full_unstemmed | Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_short | Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_sort | effects of standardized hydro alcoholic extract of vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients a randomized double blind and placebo controlled clinical trial |
| topic | Vaccinium arctostaphylos Hypertension Diabetes Mellitus Dyslipidemia |
| url | http://ajp.mums.ac.ir/article_11588_6fedfe9284a8f018f3379eb17ded2e1e.pdf |
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