A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery
A cure for type 2 diabetes was once a mere dream but has now become a tangible and achievable goal with the unforeseen success of bariatric surgery in the treatment of both obesity and type 2 diabetes. Popular bariatric procedures such as Roux-en-Y gastric bypass and sleeve gastrectomy exhibit high...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2014-12-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-406.pdf |
| _version_ | 1811212549313527808 |
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| author | Young Min Cho |
| author_facet | Young Min Cho |
| author_sort | Young Min Cho |
| collection | DOAJ |
| description | A cure for type 2 diabetes was once a mere dream but has now become a tangible and achievable goal with the unforeseen success of bariatric surgery in the treatment of both obesity and type 2 diabetes. Popular bariatric procedures such as Roux-en-Y gastric bypass and sleeve gastrectomy exhibit high rates of diabetes remission or marked improvement in glycemic control. However, the mechanism of diabetes remission following these procedures is still elusive and appears to be very complex and encompasses multiple anatomical and physiological changes. In this article, calorie restriction, improved β-cell function, improved insulin sensitivity, and alterations in gut physiology, bile acid metabolism, and gut microbiota are reviewed as potential mechanisms of diabetes remission after Roux-en-Y gastric bypass and sleeve gastrectomy. |
| first_indexed | 2024-04-12T05:30:54Z |
| format | Article |
| id | doaj.art-092ad1b02d0a4ef78888ec425e4180d4 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-12T05:30:54Z |
| publishDate | 2014-12-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-092ad1b02d0a4ef78888ec425e4180d42022-12-22T03:46:04ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872014-12-0138640641510.4093/dmj.2014.38.6.40614649A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric SurgeryYoung Min ChoA cure for type 2 diabetes was once a mere dream but has now become a tangible and achievable goal with the unforeseen success of bariatric surgery in the treatment of both obesity and type 2 diabetes. Popular bariatric procedures such as Roux-en-Y gastric bypass and sleeve gastrectomy exhibit high rates of diabetes remission or marked improvement in glycemic control. However, the mechanism of diabetes remission following these procedures is still elusive and appears to be very complex and encompasses multiple anatomical and physiological changes. In this article, calorie restriction, improved β-cell function, improved insulin sensitivity, and alterations in gut physiology, bile acid metabolism, and gut microbiota are reviewed as potential mechanisms of diabetes remission after Roux-en-Y gastric bypass and sleeve gastrectomy.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-406.pdfBariatric surgeryDiabetes mellitus, type 2ObesityRoux-en-Y gastric bypassSleeve gastrectomy |
| spellingShingle | Young Min Cho A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery Diabetes & Metabolism Journal Bariatric surgery Diabetes mellitus, type 2 Obesity Roux-en-Y gastric bypass Sleeve gastrectomy |
| title | A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery |
| title_full | A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery |
| title_fullStr | A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery |
| title_full_unstemmed | A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery |
| title_short | A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery |
| title_sort | gut feeling to cure diabetes potential mechanisms of diabetes remission after bariatric surgery |
| topic | Bariatric surgery Diabetes mellitus, type 2 Obesity Roux-en-Y gastric bypass Sleeve gastrectomy |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-406.pdf |
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