Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T
Geometric distortion is a major limiting factor for spatial specificity in high-resolution fMRI using EPI readouts and is exacerbated at higher field strengths due to increased B0 field inhomogeneity. Prominent correction schemes are based on B0 field-mapping or acquiring reverse phase-encoded (reve...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923004457 |
| _version_ | 1797727689254109184 |
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| author | Vahid Malekian Nadine N Graedel Alice Hickling Ali Aghaeifar Barbara Dymerska Nadège Corbin Oliver Josephs Eleanor A. Maguire Martina F. Callaghan |
| author_facet | Vahid Malekian Nadine N Graedel Alice Hickling Ali Aghaeifar Barbara Dymerska Nadège Corbin Oliver Josephs Eleanor A. Maguire Martina F. Callaghan |
| author_sort | Vahid Malekian |
| collection | DOAJ |
| description | Geometric distortion is a major limiting factor for spatial specificity in high-resolution fMRI using EPI readouts and is exacerbated at higher field strengths due to increased B0 field inhomogeneity. Prominent correction schemes are based on B0 field-mapping or acquiring reverse phase-encoded (reversed-PE) data. However, to date, comparisons of these techniques in the context of fMRI have only been performed on 2DEPI data, either at lower field or lower resolution. In this study, we investigate distortion compensation in the context of sub-millimetre 3DEPI data at 7T. B0 field-mapping and reversed-PE distortion correction techniques were applied to both partial coverage BOLD-weighted and whole brain MT-weighted 3DEPI data with matched distortion. Qualitative assessment showed overall improvement in cortical alignment for both correction techniques in both 3DEPI fMRI and whole-brain MT-3DEPI datasets. The distortion-corrected MT-3DEPI images were quantitatively evaluated by comparing cortical alignment with an anatomical reference using dice coefficient (DC) and correlation ratio (CR) measures. These showed that B0 field-mapping and reversed-PE methods both improved correspondence between the MT-3DEPI and anatomical data, with more substantial improvements consistently obtained using the reversed-PE approach. Regional analyses demonstrated that the largest benefit of distortion correction, and in particular of the reversed-PE approach, occurred in frontal and temporal regions where susceptibility-induced distortions are known to be greatest, but had not led to complete signal dropout. In conclusion, distortion correction based on reversed-PE data has shown the greater capacity for achieving faithful alignment with anatomical data in the context of high-resolution fMRI at 7T using 3DEPI. |
| first_indexed | 2024-03-12T11:03:07Z |
| format | Article |
| id | doaj.art-092ce4b984954c6c87207459e07f502c |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-12T11:03:07Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-092ce4b984954c6c87207459e07f502c2023-09-02T04:31:11ZengElsevierNeuroImage1095-95722023-10-01279120294Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7TVahid Malekian0Nadine N Graedel1Alice Hickling2Ali Aghaeifar3Barbara Dymerska4Nadège Corbin5Oliver Josephs6Eleanor A. Maguire7Martina F. Callaghan8Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UK; Corresponding author at: Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3AR, UK.Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UKWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UKWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UK; MR Research Collaborations, Siemens Healthcare Limited, Frimley, UKWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UKWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UK; Centre de Résonance Magnétique des Systèmes Biologiques, CNRS‐University Bordeaux, Bordeaux, FranceWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UKWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UKWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, UKGeometric distortion is a major limiting factor for spatial specificity in high-resolution fMRI using EPI readouts and is exacerbated at higher field strengths due to increased B0 field inhomogeneity. Prominent correction schemes are based on B0 field-mapping or acquiring reverse phase-encoded (reversed-PE) data. However, to date, comparisons of these techniques in the context of fMRI have only been performed on 2DEPI data, either at lower field or lower resolution. In this study, we investigate distortion compensation in the context of sub-millimetre 3DEPI data at 7T. B0 field-mapping and reversed-PE distortion correction techniques were applied to both partial coverage BOLD-weighted and whole brain MT-weighted 3DEPI data with matched distortion. Qualitative assessment showed overall improvement in cortical alignment for both correction techniques in both 3DEPI fMRI and whole-brain MT-3DEPI datasets. The distortion-corrected MT-3DEPI images were quantitatively evaluated by comparing cortical alignment with an anatomical reference using dice coefficient (DC) and correlation ratio (CR) measures. These showed that B0 field-mapping and reversed-PE methods both improved correspondence between the MT-3DEPI and anatomical data, with more substantial improvements consistently obtained using the reversed-PE approach. Regional analyses demonstrated that the largest benefit of distortion correction, and in particular of the reversed-PE approach, occurred in frontal and temporal regions where susceptibility-induced distortions are known to be greatest, but had not led to complete signal dropout. In conclusion, distortion correction based on reversed-PE data has shown the greater capacity for achieving faithful alignment with anatomical data in the context of high-resolution fMRI at 7T using 3DEPI.http://www.sciencedirect.com/science/article/pii/S1053811923004457Distortion correctionfMRIEPIUltra high fieldHigh-resolutionMagnetisation transfer |
| spellingShingle | Vahid Malekian Nadine N Graedel Alice Hickling Ali Aghaeifar Barbara Dymerska Nadège Corbin Oliver Josephs Eleanor A. Maguire Martina F. Callaghan Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T NeuroImage Distortion correction fMRI EPI Ultra high field High-resolution Magnetisation transfer |
| title | Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T |
| title_full | Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T |
| title_fullStr | Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T |
| title_full_unstemmed | Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T |
| title_short | Mitigating susceptibility-induced distortions in high-resolution 3DEPI fMRI at 7T |
| title_sort | mitigating susceptibility induced distortions in high resolution 3depi fmri at 7t |
| topic | Distortion correction fMRI EPI Ultra high field High-resolution Magnetisation transfer |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923004457 |
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