Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer?
ABSTRACT Purpose: Detection rate for anterior prostate cancer (PCa) in men who underwent initial and repeat biopsy has been prospectively evaluated. Materials and Methods: From January 2013 to March 2014, 400 patients all of Caucasian origin (median age 63.5 years) underwent initial (285 cases) an...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2015-10-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000500844&lng=en&tlng=en |
| _version_ | 1828178694188826624 |
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| author | Pietro Pepe Michele Pennisi Filippo Fraggetta |
| author_facet | Pietro Pepe Michele Pennisi Filippo Fraggetta |
| author_sort | Pietro Pepe |
| collection | DOAJ |
| description | ABSTRACT Purpose: Detection rate for anterior prostate cancer (PCa) in men who underwent initial and repeat biopsy has been prospectively evaluated. Materials and Methods: From January 2013 to March 2014, 400 patients all of Caucasian origin (median age 63.5 years) underwent initial (285 cases) and repeat (115 cases) prostate biopsy; all the men had negative digital rectal examination and the indications to biopsy were: PSA values > 10 ng/mL, PSA between 4.1-10 or 2.6-4 ng/mL with free/total PSA≤25% and ≤20%, respectively. A median of 22 (initial biopsy) and 31 cores (repeat biopsy) were transperineally performed including 4 cores of the anterior zone (AZ) and 4 cores of the AZ plus 2 cores of the transition zone (TZ), respectively. Results: Median PSA was 7.9 ng/mL; overall, a PCa was found in 180 (45%) patients: in 135 (47.4%) and 45 (36%) of the men who underwent initial and repeat biopsy, respectively. An exclusive PCa of the anterior zone was found in the 8.9 (initial biopsy) vs 13.3% (repeat biopsy) of the men: a single microfocus of cancer was found in the 61.2% of the cases; moreover, in 7 out 18 AZ PCa the biopsy histology was predictive of significant cancer in 2 (28.5%) and 5 (71.5%) men who underwent initial and repeat biopsy, respectively. Conclusions: However AZ biopsies increased detection rate for PCa (10% of the cases), the majority of AZ PCa with histological findings predictive of clinically significant cancer were found at repeat biopsy (about 70% of the cases). |
| first_indexed | 2024-04-12T05:19:52Z |
| format | Article |
| id | doaj.art-092d9f855e21447d933cbc5a04cb26c1 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-04-12T05:19:52Z |
| publishDate | 2015-10-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-092d9f855e21447d933cbc5a04cb26c12022-12-22T03:46:30ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192015-10-0141584484810.1590/S1677-5538.IBJU.2014.0234S1677-55382015000500844Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer?Pietro PepeMichele PennisiFilippo FraggettaABSTRACT Purpose: Detection rate for anterior prostate cancer (PCa) in men who underwent initial and repeat biopsy has been prospectively evaluated. Materials and Methods: From January 2013 to March 2014, 400 patients all of Caucasian origin (median age 63.5 years) underwent initial (285 cases) and repeat (115 cases) prostate biopsy; all the men had negative digital rectal examination and the indications to biopsy were: PSA values > 10 ng/mL, PSA between 4.1-10 or 2.6-4 ng/mL with free/total PSA≤25% and ≤20%, respectively. A median of 22 (initial biopsy) and 31 cores (repeat biopsy) were transperineally performed including 4 cores of the anterior zone (AZ) and 4 cores of the AZ plus 2 cores of the transition zone (TZ), respectively. Results: Median PSA was 7.9 ng/mL; overall, a PCa was found in 180 (45%) patients: in 135 (47.4%) and 45 (36%) of the men who underwent initial and repeat biopsy, respectively. An exclusive PCa of the anterior zone was found in the 8.9 (initial biopsy) vs 13.3% (repeat biopsy) of the men: a single microfocus of cancer was found in the 61.2% of the cases; moreover, in 7 out 18 AZ PCa the biopsy histology was predictive of significant cancer in 2 (28.5%) and 5 (71.5%) men who underwent initial and repeat biopsy, respectively. Conclusions: However AZ biopsies increased detection rate for PCa (10% of the cases), the majority of AZ PCa with histological findings predictive of clinically significant cancer were found at repeat biopsy (about 70% of the cases).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000500844&lng=en&tlng=enProstatic NeoplasmsProstateBiopsy |
| spellingShingle | Pietro Pepe Michele Pennisi Filippo Fraggetta Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer? International Brazilian Journal of Urology Prostatic Neoplasms Prostate Biopsy |
| title | Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer? |
| title_full | Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer? |
| title_fullStr | Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer? |
| title_full_unstemmed | Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer? |
| title_short | Anterior prostate biopsy at initial and repeat evaluation: is it useful to detect significant prostate cancer? |
| title_sort | anterior prostate biopsy at initial and repeat evaluation is it useful to detect significant prostate cancer |
| topic | Prostatic Neoplasms Prostate Biopsy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000500844&lng=en&tlng=en |
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