Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report
Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for ex vivo drug testing to guide therapy selection in th...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-022-00150-3 |
| _version_ | 1828335275426709504 |
|---|---|
| author | Marie-Anne Meier Sandro Nuciforo Mairene Coto-Llerena John Gallon Matthias S. Matter Caner Ercan Jürg Vosbeck Luigi M. Terracciano Savas D. Soysal Daniel Boll Otto Kollmar Raphaël Delaloye Salvatore Piscuoglio Markus H. Heim |
| author_facet | Marie-Anne Meier Sandro Nuciforo Mairene Coto-Llerena John Gallon Matthias S. Matter Caner Ercan Jürg Vosbeck Luigi M. Terracciano Savas D. Soysal Daniel Boll Otto Kollmar Raphaël Delaloye Salvatore Piscuoglio Markus H. Heim |
| author_sort | Marie-Anne Meier |
| collection | DOAJ |
| description | Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for ex vivo drug testing to guide therapy selection in the patient. |
| first_indexed | 2024-04-13T21:44:02Z |
| format | Article |
| id | doaj.art-092df1cdee254031870f4d0caaa0bd75 |
| institution | Directory Open Access Journal |
| issn | 2730-664X |
| language | English |
| last_indexed | 2024-04-13T21:44:02Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj.art-092df1cdee254031870f4d0caaa0bd752022-12-22T02:28:38ZengNature PortfolioCommunications Medicine2730-664X2022-07-01211810.1038/s43856-022-00150-3Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case reportMarie-Anne Meier0Sandro Nuciforo1Mairene Coto-Llerena2John Gallon3Matthias S. Matter4Caner Ercan5Jürg Vosbeck6Luigi M. Terracciano7Savas D. Soysal8Daniel Boll9Otto Kollmar10Raphaël Delaloye11Salvatore Piscuoglio12Markus H. Heim13Department of Biomedicine, University Hospital and University of BaselDepartment of Biomedicine, University Hospital and University of BaselDepartment of Biomedicine, University Hospital and University of BaselDepartment of Biomedicine, University Hospital and University of BaselInstitute of Medical Genetics and Pathology, University Hospital BaselInstitute of Medical Genetics and Pathology, University Hospital BaselInstitute of Medical Genetics and Pathology, University Hospital BaselDepartment of Anatomic Pathology, IRCCS Humanitas Research Hospital, RozzanoClarunis University Center for Gastrointestinal and Liver DiseasesRadiology and Nuclear Medicine, University Hospital BaselClarunis University Center for Gastrointestinal and Liver DiseasesDepartment of Oncology, University Hospital BaselDepartment of Biomedicine, University Hospital and University of BaselDepartment of Biomedicine, University Hospital and University of BaselMeier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for ex vivo drug testing to guide therapy selection in the patient.https://doi.org/10.1038/s43856-022-00150-3 |
| spellingShingle | Marie-Anne Meier Sandro Nuciforo Mairene Coto-Llerena John Gallon Matthias S. Matter Caner Ercan Jürg Vosbeck Luigi M. Terracciano Savas D. Soysal Daniel Boll Otto Kollmar Raphaël Delaloye Salvatore Piscuoglio Markus H. Heim Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report Communications Medicine |
| title | Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report |
| title_full | Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report |
| title_fullStr | Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report |
| title_full_unstemmed | Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report |
| title_short | Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report |
| title_sort | patient derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation a case report |
| url | https://doi.org/10.1038/s43856-022-00150-3 |
| work_keys_str_mv | AT marieannemeier patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT sandronuciforo patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT mairenecotollerena patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT johngallon patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT matthiassmatter patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT canerercan patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT jurgvosbeck patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT luigimterracciano patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT savasdsoysal patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT danielboll patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT ottokollmar patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT raphaeldelaloye patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT salvatorepiscuoglio patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport AT markushheim patientderivedtumororganoidsforpersonalizedmedicineinapatientwithrarehepatocellularcarcinomawithneuroendocrinedifferentiationacasereport |