<i>Brucella</i> Genomics: Macro and Micro Evolution
<i>Brucella</i> organisms are responsible for one of the most widespread bacterial zoonoses, named brucellosis. The disease affects several species of animals, including humans. One of the most intriguing aspects of the brucellae is that the various species show a ~97% similarity at the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/20/7749 |
| _version_ | 1797550432574242816 |
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| author | Marcela Suárez-Esquivel Esteban Chaves-Olarte Edgardo Moreno Caterina Guzmán-Verri |
| author_facet | Marcela Suárez-Esquivel Esteban Chaves-Olarte Edgardo Moreno Caterina Guzmán-Verri |
| author_sort | Marcela Suárez-Esquivel |
| collection | DOAJ |
| description | <i>Brucella</i> organisms are responsible for one of the most widespread bacterial zoonoses, named brucellosis. The disease affects several species of animals, including humans. One of the most intriguing aspects of the brucellae is that the various species show a ~97% similarity at the genome level. Still, the distinct <i>Brucella</i> species display different host preferences, zoonotic risk, and virulence. After 133 years of research, there are many aspects of the <i>Brucella</i> biology that remain poorly understood, such as host adaptation and virulence mechanisms. A strategy to understand these characteristics focuses on the relationship between the genomic diversity and host preference of the various <i>Brucella</i> species. Pseudogenization, genome reduction, single nucleotide polymorphism variation, number of tandem repeats, and mobile genetic elements are unveiled markers for host adaptation and virulence. Understanding the mechanisms of genome variability in the <i>Brucella</i> genus is relevant to comprehend the emergence of pathogens. |
| first_indexed | 2024-03-10T15:29:13Z |
| format | Article |
| id | doaj.art-092e9b493606479a8bf8a0f2fa27e6df |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:29:13Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-092e9b493606479a8bf8a0f2fa27e6df2023-11-20T17:45:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012120774910.3390/ijms21207749<i>Brucella</i> Genomics: Macro and Micro EvolutionMarcela Suárez-Esquivel0Esteban Chaves-Olarte1Edgardo Moreno2Caterina Guzmán-Verri3Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia 3000, Costa RicaCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José 1180, Costa RicaPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia 3000, Costa RicaPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia 3000, Costa Rica<i>Brucella</i> organisms are responsible for one of the most widespread bacterial zoonoses, named brucellosis. The disease affects several species of animals, including humans. One of the most intriguing aspects of the brucellae is that the various species show a ~97% similarity at the genome level. Still, the distinct <i>Brucella</i> species display different host preferences, zoonotic risk, and virulence. After 133 years of research, there are many aspects of the <i>Brucella</i> biology that remain poorly understood, such as host adaptation and virulence mechanisms. A strategy to understand these characteristics focuses on the relationship between the genomic diversity and host preference of the various <i>Brucella</i> species. Pseudogenization, genome reduction, single nucleotide polymorphism variation, number of tandem repeats, and mobile genetic elements are unveiled markers for host adaptation and virulence. Understanding the mechanisms of genome variability in the <i>Brucella</i> genus is relevant to comprehend the emergence of pathogens.https://www.mdpi.com/1422-0067/21/20/7749<i>Brucella</i>brucellosisgenome reductionpseudogeneIS<i>711</i>SNPs |
| spellingShingle | Marcela Suárez-Esquivel Esteban Chaves-Olarte Edgardo Moreno Caterina Guzmán-Verri <i>Brucella</i> Genomics: Macro and Micro Evolution International Journal of Molecular Sciences <i>Brucella</i> brucellosis genome reduction pseudogene IS<i>711</i> SNPs |
| title | <i>Brucella</i> Genomics: Macro and Micro Evolution |
| title_full | <i>Brucella</i> Genomics: Macro and Micro Evolution |
| title_fullStr | <i>Brucella</i> Genomics: Macro and Micro Evolution |
| title_full_unstemmed | <i>Brucella</i> Genomics: Macro and Micro Evolution |
| title_short | <i>Brucella</i> Genomics: Macro and Micro Evolution |
| title_sort | i brucella i genomics macro and micro evolution |
| topic | <i>Brucella</i> brucellosis genome reduction pseudogene IS<i>711</i> SNPs |
| url | https://www.mdpi.com/1422-0067/21/20/7749 |
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