68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer
We present the first study performed in Saudi Arabia to evaluate 68Ga-PSMA PET/CT in prostate cancer (PCa) initial diagnosis and its added value in bone metastases (BM) diagnosis in such patients. Twenty-six male patients underwent prostate histopathological examination and all imaging studies (68Ga...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
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International Medical Research and Development Corporation
2024-03-01
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Series: | International Journal of Biomedicine |
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Online Access: | http://www.ijbm.org/articles/i53/ijbm_14(1)_oa10.pdf |
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author | Sahar Mansour Meshael Al-Khalaf Sarah Al-Hantoshi Mead Al-Mutairi Fatima Al-Asqah Nouf Al-Subaie Sadeem Al-Qarni Futun Suwaylim Rawan F. Alkhodiri Ola Faden Abdulrahman Albatly |
author_facet | Sahar Mansour Meshael Al-Khalaf Sarah Al-Hantoshi Mead Al-Mutairi Fatima Al-Asqah Nouf Al-Subaie Sadeem Al-Qarni Futun Suwaylim Rawan F. Alkhodiri Ola Faden Abdulrahman Albatly |
author_sort | Sahar Mansour |
collection | DOAJ |
description | We present the first study performed in Saudi Arabia to evaluate 68Ga-PSMA PET/CT in prostate cancer (PCa) initial diagnosis and its added value in bone metastases (BM) diagnosis in such patients. Twenty-six male patients underwent prostate histopathological examination and all imaging studies (68Ga-PSMA PET/CT and CT); all of them were confirmed with high-grade PCa. Patients' mean PSA levels and Gleason score were 5.12±1.12 and 7.0±0.9, respectively. 68Ga-PSMA PET/CT (20/26; sensitivity of 76.9%) was superior to traditional CT (18/26; sensitivity of 69.2%) in PCa detection. There was a non-significant association (P=0.206) between patients' age and BM. Based on bone scintigraphy (BS), in patients without BM (n=16), 68Ga-PSMA PET/CT detected metastasis-suspicious lesions in six patients (37.5%) and negative results in ten patients (62.5%). 68Ga-PSMA PET/CT showed no false-negative cases among patients with confirmed BM using BS.
In conclusion, 68Ga-PSMA PET/CT performed well in PCa initial diagnosis in Saudi male patients with high-grade tumors. 68Ga-PSMA PET/CT also accurately detected BM in all PCa patients with confirmed BM by BS. Larger prospective studies are urgently required to compare 68Ga-PSMA PET/CT diagnostic performance with other standard modalities in PCa and BM diagnosis. |
first_indexed | 2024-03-07T17:16:28Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 2158-0510 2158-0529 |
language | English |
last_indexed | 2024-03-07T17:16:28Z |
publishDate | 2024-03-01 |
publisher | International Medical Research and Development Corporation |
record_format | Article |
series | International Journal of Biomedicine |
spelling | doaj.art-092fc51e1e5945668a49edeb45b0caa42024-03-02T21:48:46ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292024-03-01141727610.21103/Article14(1)_OA1068Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate CancerSahar Mansour0Meshael Al-Khalaf1Sarah Al-Hantoshi2Mead Al-Mutairi3Fatima Al-Asqah4Nouf Al-Subaie5Sadeem Al-Qarni6Futun Suwaylim7Rawan F. Alkhodiri8Ola Faden9Abdulrahman Albatly10Radiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaRadiological Sciences Department, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaNuclear Medicine Department, King Abdulaziz Medical City, Riyadh, Saudi ArabiaNuclear Medicine Department, King Abdulaziz Medical City, Riyadh, Saudi ArabiaNuclear Medicine Department, Prince Sultan Military Medical City, Riyadh, Saudi ArabiaWe present the first study performed in Saudi Arabia to evaluate 68Ga-PSMA PET/CT in prostate cancer (PCa) initial diagnosis and its added value in bone metastases (BM) diagnosis in such patients. Twenty-six male patients underwent prostate histopathological examination and all imaging studies (68Ga-PSMA PET/CT and CT); all of them were confirmed with high-grade PCa. Patients' mean PSA levels and Gleason score were 5.12±1.12 and 7.0±0.9, respectively. 68Ga-PSMA PET/CT (20/26; sensitivity of 76.9%) was superior to traditional CT (18/26; sensitivity of 69.2%) in PCa detection. There was a non-significant association (P=0.206) between patients' age and BM. Based on bone scintigraphy (BS), in patients without BM (n=16), 68Ga-PSMA PET/CT detected metastasis-suspicious lesions in six patients (37.5%) and negative results in ten patients (62.5%). 68Ga-PSMA PET/CT showed no false-negative cases among patients with confirmed BM using BS. In conclusion, 68Ga-PSMA PET/CT performed well in PCa initial diagnosis in Saudi male patients with high-grade tumors. 68Ga-PSMA PET/CT also accurately detected BM in all PCa patients with confirmed BM by BS. Larger prospective studies are urgently required to compare 68Ga-PSMA PET/CT diagnostic performance with other standard modalities in PCa and BM diagnosis. http://www.ijbm.org/articles/i53/ijbm_14(1)_oa10.pdfprostate cancer68ga-psma pet/ctdiagnosisbone metastasissensitivity |
spellingShingle | Sahar Mansour Meshael Al-Khalaf Sarah Al-Hantoshi Mead Al-Mutairi Fatima Al-Asqah Nouf Al-Subaie Sadeem Al-Qarni Futun Suwaylim Rawan F. Alkhodiri Ola Faden Abdulrahman Albatly 68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer International Journal of Biomedicine prostate cancer 68ga-psma pet/ct diagnosis bone metastasis sensitivity |
title | 68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer |
title_full | 68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer |
title_fullStr | 68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer |
title_full_unstemmed | 68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer |
title_short | 68Ga-PSMA PET/CT in Initial Diagnosis and Bone Metastasis Evaluation in Saudi Patients with High-Grade Prostate Cancer |
title_sort | 68ga psma pet ct in initial diagnosis and bone metastasis evaluation in saudi patients with high grade prostate cancer |
topic | prostate cancer 68ga-psma pet/ct diagnosis bone metastasis sensitivity |
url | http://www.ijbm.org/articles/i53/ijbm_14(1)_oa10.pdf |
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