Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli

Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli

IntroductionAntibiotic resistance has posed a serious challenge to global public health. With the increasing resistance emergence of E. coli and mortality caused by drug-resistant E. coli infections, it is urgent to develop novel antibiotics.MethodsBy high-throughput screening assay, we found a bioa...

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Bibliographic Details
Main Authors: Linhui Li, Pengfei She, Shasha Liu, Yimin Li, Zehao Li, Yifan Yang, Linying Zhou, Yong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Microbiology
Subjects:
small molecules
antibiotic combination
antibacterial
polymyxin
Escherichia coli
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1078318/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.1078318/full

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