Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine
There are several conditions that lead to female infertility, where traditional or conventional treatments have limited efficacy. In these challenging scenarios, stem cell (SC) therapies have been investigated as alternative treatment strategies. Human umbilical cord (hUC) mesenchymal stem cells (hU...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/24/15942 |
| _version_ | 1797406817157906432 |
|---|---|
| author | Adolfo Rodríguez-Eguren María Gómez-Álvarez Emilio Francés-Herrero Mónica Romeu Hortensia Ferrero Emre Seli Irene Cervelló |
| author_facet | Adolfo Rodríguez-Eguren María Gómez-Álvarez Emilio Francés-Herrero Mónica Romeu Hortensia Ferrero Emre Seli Irene Cervelló |
| author_sort | Adolfo Rodríguez-Eguren |
| collection | DOAJ |
| description | There are several conditions that lead to female infertility, where traditional or conventional treatments have limited efficacy. In these challenging scenarios, stem cell (SC) therapies have been investigated as alternative treatment strategies. Human umbilical cord (hUC) mesenchymal stem cells (hUC-MSC), along with their secreted paracrine factors, extracts, and biomolecules, have emerged as promising therapeutic alternatives in regenerative medicine, due to their remarkable potential to promote anti-inflammatory and regenerative processes more efficiently than other autologous treatments. Similarly, hUC blood derivatives, such as platelet-rich plasma (PRP), or isolated plasma elements, such as growth factors, have also demonstrated potential. This literature review aims to summarize the recent therapeutic advances based on hUC-MSCs, hUC blood, and/or other plasma derivatives (e.g., extracellular vesicles, hUC-PRP, and growth factors) in the context of female reproductive medicine. We present an in-depth analysis of the principal molecules mediating tissue regeneration, compiling the application of these therapies in preclinical and clinical studies, within the context of the human reproductive tract. Despite the recent advances in bioengineering strategies that sustain delivery and amplify the scope of the therapeutic benefits, further clinical trials are required prior to the wide implementation of these alternative therapies in reproductive medicine. |
| first_indexed | 2024-03-09T03:32:06Z |
| format | Article |
| id | doaj.art-09340d8acf5a4934a02477ab0df51943 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:32:06Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-09340d8acf5a4934a02477ab0df519432023-12-03T14:53:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241594210.3390/ijms232415942Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive MedicineAdolfo Rodríguez-Eguren0María Gómez-Álvarez1Emilio Francés-Herrero2Mónica Romeu3Hortensia Ferrero4Emre Seli5Irene Cervelló6IVI Foundation, Health Research Institute La Fe, 46026 Valencia, SpainIVI Foundation, Health Research Institute La Fe, 46026 Valencia, SpainIVI Foundation, Health Research Institute La Fe, 46026 Valencia, SpainGynecological Service, Consortium General University Hospital of Valencia, 46014 Valencia, SpainIVI Foundation, Health Research Institute La Fe, 46026 Valencia, SpainDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 05610, USAIVI Foundation, Health Research Institute La Fe, 46026 Valencia, SpainThere are several conditions that lead to female infertility, where traditional or conventional treatments have limited efficacy. In these challenging scenarios, stem cell (SC) therapies have been investigated as alternative treatment strategies. Human umbilical cord (hUC) mesenchymal stem cells (hUC-MSC), along with their secreted paracrine factors, extracts, and biomolecules, have emerged as promising therapeutic alternatives in regenerative medicine, due to their remarkable potential to promote anti-inflammatory and regenerative processes more efficiently than other autologous treatments. Similarly, hUC blood derivatives, such as platelet-rich plasma (PRP), or isolated plasma elements, such as growth factors, have also demonstrated potential. This literature review aims to summarize the recent therapeutic advances based on hUC-MSCs, hUC blood, and/or other plasma derivatives (e.g., extracellular vesicles, hUC-PRP, and growth factors) in the context of female reproductive medicine. We present an in-depth analysis of the principal molecules mediating tissue regeneration, compiling the application of these therapies in preclinical and clinical studies, within the context of the human reproductive tract. Despite the recent advances in bioengineering strategies that sustain delivery and amplify the scope of the therapeutic benefits, further clinical trials are required prior to the wide implementation of these alternative therapies in reproductive medicine.https://www.mdpi.com/1422-0067/23/24/15942umbilical cordfemale reproductionumbilical cord mesenchymal stem cellsstem cell therapyplatelet-rich plasmaexosomes |
| spellingShingle | Adolfo Rodríguez-Eguren María Gómez-Álvarez Emilio Francés-Herrero Mónica Romeu Hortensia Ferrero Emre Seli Irene Cervelló Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine International Journal of Molecular Sciences umbilical cord female reproduction umbilical cord mesenchymal stem cells stem cell therapy platelet-rich plasma exosomes |
| title | Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine |
| title_full | Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine |
| title_fullStr | Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine |
| title_full_unstemmed | Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine |
| title_short | Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine |
| title_sort | human umbilical cord based therapeutics stem cells and blood derivatives for female reproductive medicine |
| topic | umbilical cord female reproduction umbilical cord mesenchymal stem cells stem cell therapy platelet-rich plasma exosomes |
| url | https://www.mdpi.com/1422-0067/23/24/15942 |
| work_keys_str_mv | AT adolforodriguezeguren humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine AT mariagomezalvarez humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine AT emiliofrancesherrero humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine AT monicaromeu humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine AT hortensiaferrero humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine AT emreseli humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine AT irenecervello humanumbilicalcordbasedtherapeuticsstemcellsandbloodderivativesforfemalereproductivemedicine |