The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study
This study investigates the effects of two light conditions on innate proinflammatory IL-6 cytokines and the cortisol awakening response. The between-subject experiment was conducted with 55 healthy adult-males (aged M bright = 24.40, SD = 4.58; M dim = 25.47, SD = 4.96) in a standardized sleep labo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622000941 |
| _version_ | 1811206627751100416 |
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| author | Katja Petrowski Bjarne Schmalbach Mona Linhardt Liza Mekschrat Nicolas Rohleder |
| author_facet | Katja Petrowski Bjarne Schmalbach Mona Linhardt Liza Mekschrat Nicolas Rohleder |
| author_sort | Katja Petrowski |
| collection | DOAJ |
| description | This study investigates the effects of two light conditions on innate proinflammatory IL-6 cytokines and the cortisol awakening response. The between-subject experiment was conducted with 55 healthy adult-males (aged M bright = 24.40, SD = 4.58; M dim = 25.47, SD = 4.96) in a standardized sleep laboratory setting with 60-min light exposure post-awakening. Cortisol significantly increased with bright light exposure as compared to dim light (significant interaction effect). As for IL-6, the main effects of time and light condition were significant, however, the interaction effect between light and time was insignificant. Results replicate stimulatory effects of bright light on cortisol. In general, IL-6 concentrations decreased in both light conditions; however, bright light graphically showed higher concentrations 45–90 min after exposure in comparison to dim light, thus bright light has a potential stimulatory effect on IL-6 production. |
| first_indexed | 2024-04-12T03:50:21Z |
| format | Article |
| id | doaj.art-093505d18c4b44c48685a7588518566c |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-04-12T03:50:21Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-093505d18c4b44c48685a7588518566c2022-12-22T03:48:59ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-11-0125100504The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled studyKatja Petrowski0Bjarne Schmalbach1Mona Linhardt2Liza Mekschrat3Nicolas Rohleder4Medical Psychology & Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Department of Internal Medicine III, Dresden University of Technology, Dresden, Germany; Corresponding author. Chair of Health Psychology, Department of Psychology, Friedrich-Alexander University, Nägelsbachstr. 49a, 91052, Erlangen, Germany.Medical Psychology & Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Department of Psychology, University of Muenster, GermanyMedical Psychology & Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, GermanyMedical Psychology & Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, GermanyChair of Health Psychology, Department of Psychology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GermanyThis study investigates the effects of two light conditions on innate proinflammatory IL-6 cytokines and the cortisol awakening response. The between-subject experiment was conducted with 55 healthy adult-males (aged M bright = 24.40, SD = 4.58; M dim = 25.47, SD = 4.96) in a standardized sleep laboratory setting with 60-min light exposure post-awakening. Cortisol significantly increased with bright light exposure as compared to dim light (significant interaction effect). As for IL-6, the main effects of time and light condition were significant, however, the interaction effect between light and time was insignificant. Results replicate stimulatory effects of bright light on cortisol. In general, IL-6 concentrations decreased in both light conditions; however, bright light graphically showed higher concentrations 45–90 min after exposure in comparison to dim light, thus bright light has a potential stimulatory effect on IL-6 production.http://www.sciencedirect.com/science/article/pii/S2666354622000941Non-visual light-effectsMelanopsin-expressing-retinal-ganglion-cellsImmune parameterCircadian rhythmIL-6Innate proinflammatory cytokines |
| spellingShingle | Katja Petrowski Bjarne Schmalbach Mona Linhardt Liza Mekschrat Nicolas Rohleder The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study Brain, Behavior, & Immunity - Health Non-visual light-effects Melanopsin-expressing-retinal-ganglion-cells Immune parameter Circadian rhythm IL-6 Innate proinflammatory cytokines |
| title | The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study |
| title_full | The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study |
| title_fullStr | The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study |
| title_full_unstemmed | The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study |
| title_short | The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study |
| title_sort | inflammatory immune system after wake up in healthy male individuals a highly standardized and controlled study |
| topic | Non-visual light-effects Melanopsin-expressing-retinal-ganglion-cells Immune parameter Circadian rhythm IL-6 Innate proinflammatory cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622000941 |
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