Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat
Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes induced by long-term high fat and high fructose die...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001378 |
| _version_ | 1827957425997611008 |
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| author | Che-Wei Lin Chun-Hung Lin Ya-Wen Hsu Tzu-Ming Pan Chun-Lin Lee |
| author_facet | Che-Wei Lin Chun-Hung Lin Ya-Wen Hsu Tzu-Ming Pan Chun-Lin Lee |
| author_sort | Che-Wei Lin |
| collection | DOAJ |
| description | Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes induced by long-term high fat and high fructose diet (HFFD) remain unclear. In this study, RMD, MS, and AK were orally administered to HFFD-fed rats for 10 weeks. The result showed that orally administered MS, AK, and RMD were able to prevent the develop-ment. MS had a more potent effect on lowering blood glucose, fructosamine, and insulin resistance, and increasing hepatic glucose transporters-2, adipocyte glucose transporters-4, and hypoxia-inducible factor 1-α. AK had a greater effect on lowering blood lipid, adipose pad, and adipose inflammatory factors (interlukin-1β, tumor necrosis factor-α, and interlukin-6) levels. Therefore, the prevention of type 2 diabetes and metabolic disorders of RMD could be mainly attributed to the synergistic effect of MS and AK. |
| first_indexed | 2024-04-09T15:20:00Z |
| format | Article |
| id | doaj.art-0935f23df63b437eb1ef9fa934f97231 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-09T15:20:00Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0935f23df63b437eb1ef9fa934f972312023-04-29T14:48:30ZengElsevierJournal of Functional Foods1756-46462023-05-01104105537Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic ratChe-Wei Lin0Chun-Hung Lin1Ya-Wen Hsu2Tzu-Ming Pan3Chun-Lin Lee4SunWay Biotech Co., Taipei, Taiwan, ROCDepartment of Life Science, National Taitung University, 369, Sec. 2, University Rd., Taitung 95092, Taiwan, ROCSunWay Biotech Co., Taipei, Taiwan, ROCSunWay Biotech Co., Taipei, Taiwan, ROC; Department of Biochemical Science and Technology, National Taiwan University, Taiwan, ROC; Corresponding authors.Department of Life Science, National Taitung University, 369, Sec. 2, University Rd., Taitung 95092, Taiwan, ROC; Corresponding authors.Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes induced by long-term high fat and high fructose diet (HFFD) remain unclear. In this study, RMD, MS, and AK were orally administered to HFFD-fed rats for 10 weeks. The result showed that orally administered MS, AK, and RMD were able to prevent the develop-ment. MS had a more potent effect on lowering blood glucose, fructosamine, and insulin resistance, and increasing hepatic glucose transporters-2, adipocyte glucose transporters-4, and hypoxia-inducible factor 1-α. AK had a greater effect on lowering blood lipid, adipose pad, and adipose inflammatory factors (interlukin-1β, tumor necrosis factor-α, and interlukin-6) levels. Therefore, the prevention of type 2 diabetes and metabolic disorders of RMD could be mainly attributed to the synergistic effect of MS and AK.http://www.sciencedirect.com/science/article/pii/S1756464623001378Red mold dioscoreaAnkaflavinMonascinMetabolic disorderGlucose intoleranceHigh-fat high-fructose diet |
| spellingShingle | Che-Wei Lin Chun-Hung Lin Ya-Wen Hsu Tzu-Ming Pan Chun-Lin Lee Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat Journal of Functional Foods Red mold dioscorea Ankaflavin Monascin Metabolic disorder Glucose intolerance High-fat high-fructose diet |
| title | Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat |
| title_full | Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat |
| title_fullStr | Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat |
| title_full_unstemmed | Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat |
| title_short | Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat |
| title_sort | monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory hypolipidemic and anti inflammatory effects in high fructose and high fat diet induced hyperglycemic rat |
| topic | Red mold dioscorea Ankaflavin Monascin Metabolic disorder Glucose intolerance High-fat high-fructose diet |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001378 |
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