CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/298 |
| _version_ | 1797198064679649280 |
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| author | O. T. Kudaeva V. O. Tkachev E. D. Gavrilova E. V. Goiman N. N. Volsky O. M. Perminova O. P. Kolesnikova |
| author_facet | O. T. Kudaeva V. O. Tkachev E. D. Gavrilova E. V. Goiman N. N. Volsky O. M. Perminova O. P. Kolesnikova |
| author_sort | O. T. Kudaeva |
| collection | DOAJ |
| description | Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology. |
| first_indexed | 2024-03-08T05:51:17Z |
| format | Article |
| id | doaj.art-0936c546bbad4f99a0485a32fd4444f8 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:55Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-0936c546bbad4f99a0485a32fd4444f82024-04-22T13:07:35ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01141-2677410.15789/1563-0625-2012-1-2-67-74295CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHDO. T. Kudaeva0V. O. Tkachev1E. D. Gavrilova2E. V. Goiman3N. N. Volsky4O. M. Perminova5O. P. Kolesnikova6НИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскAbstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology.https://www.mimmun.ru/mimmun/article/view/298chronic gvhdcytokinesimmunoglobulin e |
| spellingShingle | O. T. Kudaeva V. O. Tkachev E. D. Gavrilova E. V. Goiman N. N. Volsky O. M. Perminova O. P. Kolesnikova CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD Медицинская иммунология chronic gvhd cytokines immunoglobulin e |
| title | CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD |
| title_full | CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD |
| title_fullStr | CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD |
| title_full_unstemmed | CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD |
| title_short | CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD |
| title_sort | cytokine profile of th1 and th2 dependent variants of chronic gvhd |
| topic | chronic gvhd cytokines immunoglobulin e |
| url | https://www.mimmun.ru/mimmun/article/view/298 |
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