Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review
Thanks to their biological properties, amniotic membrane (AM), and its derivatives are considered as an attractive reservoir of stem cells and biological scaffolds for bone regenerative medicine. The objective of this systematic review was to assess the benefit of using AM and amniotic membrane-deri...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.661332/full |
| _version_ | 1818736380085272576 |
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| author | Marion Etchebarne Marion Etchebarne Jean-Christophe Fricain Jean-Christophe Fricain Halima Kerdjoudj Halima Kerdjoudj Roberta Di Pietro Roberta Di Pietro Susanne Wolbank Susanne Wolbank Florelle Gindraux Florelle Gindraux Mathilde Fenelon Mathilde Fenelon |
| author_facet | Marion Etchebarne Marion Etchebarne Jean-Christophe Fricain Jean-Christophe Fricain Halima Kerdjoudj Halima Kerdjoudj Roberta Di Pietro Roberta Di Pietro Susanne Wolbank Susanne Wolbank Florelle Gindraux Florelle Gindraux Mathilde Fenelon Mathilde Fenelon |
| author_sort | Marion Etchebarne |
| collection | DOAJ |
| description | Thanks to their biological properties, amniotic membrane (AM), and its derivatives are considered as an attractive reservoir of stem cells and biological scaffolds for bone regenerative medicine. The objective of this systematic review was to assess the benefit of using AM and amniotic membrane-derived products for bone regeneration. An electronic search of the MEDLINE—Pubmed database and the Scopus database was carried out and the selection of articles was performed following PRISMA guidelines. This systematic review included 42 articles taking into consideration the studies in which AM, amniotic-derived epithelial cells (AECs), and amniotic mesenchymal stromal cells (AMSCs) show promising results for bone regeneration in animal models. Moreover, this review also presents some commercialized products derived from AM and discusses their application modalities. Finally, AM therapeutic benefit is highlighted in the reported clinical studies. This study is the first one to systematically review the therapeutic benefits of AM and amniotic membrane-derived products for bone defect healing. The AM is a promising alternative to the commercially available membranes used for guided bone regeneration. Additionally, AECs and AMSCs associated with an appropriate scaffold may also be ideal candidates for tissue engineering strategies applied to bone healing. Here, we summarized these findings and highlighted the relevance of these different products for bone regeneration. |
| first_indexed | 2024-12-18T00:36:13Z |
| format | Article |
| id | doaj.art-09374b39bc4d4f3d97c13b772a5e61d3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-18T00:36:13Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-09374b39bc4d4f3d97c13b772a5e61d32022-12-21T21:27:01ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-05-01910.3389/fbioe.2021.661332661332Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic ReviewMarion Etchebarne0Marion Etchebarne1Jean-Christophe Fricain2Jean-Christophe Fricain3Halima Kerdjoudj4Halima Kerdjoudj5Roberta Di Pietro6Roberta Di Pietro7Susanne Wolbank8Susanne Wolbank9Florelle Gindraux10Florelle Gindraux11Mathilde Fenelon12Mathilde Fenelon13Univ. Bordeaux, INSERM, BIOTIS, U1026, Bordeaux, FranceCHU Bordeaux, Department of Maxillofacial Surgery, Bordeaux, FranceUniv. Bordeaux, INSERM, BIOTIS, U1026, Bordeaux, FranceCHU Bordeaux, Service de Chirurgie Orale, Bordeaux, FranceUniversité de Reims Champagne Ardenne, EA 4691, Biomatériaux et Inflammation en Site Osseux (BIOS), Reims, FranceUniversité de Reims Champagne Ardenne, UFR d'Odontologie, Reims, FranceDepartment of Medicine and Ageing Sciences, Gabriele D'Annunzio University of Chieti-Pescara, Chieti, ItalyStemTeCh Group, Gabriele D'Annunzio Foundation, Gabriele D'Annunzio University of Chieti-Pescara, Chieti, ItalyLudwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, AustriaAustrian Cluster for Tissue Regeneration, Vienna, Austria0Service de Chirurgie Orthopédique, Traumatologique et Plastique, CHU Besançon, Besançon, France1Laboratoire de Nanomédecine, Imagerie, Thérapeutique EA 4662, Université Bourgogne Franche-Comté, Besançon, FranceUniv. Bordeaux, INSERM, BIOTIS, U1026, Bordeaux, FranceCHU Bordeaux, Service de Chirurgie Orale, Bordeaux, FranceThanks to their biological properties, amniotic membrane (AM), and its derivatives are considered as an attractive reservoir of stem cells and biological scaffolds for bone regenerative medicine. The objective of this systematic review was to assess the benefit of using AM and amniotic membrane-derived products for bone regeneration. An electronic search of the MEDLINE—Pubmed database and the Scopus database was carried out and the selection of articles was performed following PRISMA guidelines. This systematic review included 42 articles taking into consideration the studies in which AM, amniotic-derived epithelial cells (AECs), and amniotic mesenchymal stromal cells (AMSCs) show promising results for bone regeneration in animal models. Moreover, this review also presents some commercialized products derived from AM and discusses their application modalities. Finally, AM therapeutic benefit is highlighted in the reported clinical studies. This study is the first one to systematically review the therapeutic benefits of AM and amniotic membrane-derived products for bone defect healing. The AM is a promising alternative to the commercially available membranes used for guided bone regeneration. Additionally, AECs and AMSCs associated with an appropriate scaffold may also be ideal candidates for tissue engineering strategies applied to bone healing. Here, we summarized these findings and highlighted the relevance of these different products for bone regeneration.https://www.frontiersin.org/articles/10.3389/fbioe.2021.661332/fullamniotic membraneamniotic epithelial cellsamniotic mesenchymal stromal cellsbonebone tissue engineeringregenerative medicine |
| spellingShingle | Marion Etchebarne Marion Etchebarne Jean-Christophe Fricain Jean-Christophe Fricain Halima Kerdjoudj Halima Kerdjoudj Roberta Di Pietro Roberta Di Pietro Susanne Wolbank Susanne Wolbank Florelle Gindraux Florelle Gindraux Mathilde Fenelon Mathilde Fenelon Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review Frontiers in Bioengineering and Biotechnology amniotic membrane amniotic epithelial cells amniotic mesenchymal stromal cells bone bone tissue engineering regenerative medicine |
| title | Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review |
| title_full | Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review |
| title_fullStr | Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review |
| title_full_unstemmed | Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review |
| title_short | Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review |
| title_sort | use of amniotic membrane and its derived products for bone regeneration a systematic review |
| topic | amniotic membrane amniotic epithelial cells amniotic mesenchymal stromal cells bone bone tissue engineering regenerative medicine |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.661332/full |
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