Obesity, Type 2 Diabetes, and Cancer Risk
Obesity and type 2 diabetes have both been associated with increased cancer risk and are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and dyslipidemia are associated with both obesity and type 2 diabetes and have been implicated in the obesity-cancer relationsh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.615375/full |
| _version_ | 1818577692590604288 |
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| author | Tiffany Scully Abora Ettela Derek LeRoith Derek LeRoith Emily Jane Gallagher Emily Jane Gallagher |
| author_facet | Tiffany Scully Abora Ettela Derek LeRoith Derek LeRoith Emily Jane Gallagher Emily Jane Gallagher |
| author_sort | Tiffany Scully |
| collection | DOAJ |
| description | Obesity and type 2 diabetes have both been associated with increased cancer risk and are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and dyslipidemia are associated with both obesity and type 2 diabetes and have been implicated in the obesity-cancer relationship. Multiple mechanisms have been proposed to link obesity and diabetes with cancer progression, including an increase in insulin/IGF-1 signaling, lipid and glucose uptake and metabolism, alterations in the profile of cytokines, chemokines, and adipokines, as well as changes in the adipose tissue directly adjacent to the cancer sites. This review aims to summarize and provide an update on the epidemiological and mechanistic evidence linking obesity and type 2 diabetes with cancer, focusing on the roles of insulin, lipids, and adipose tissue. |
| first_indexed | 2024-12-16T06:33:57Z |
| format | Article |
| id | doaj.art-0937af9bbfda43bdbf2d23f3c2d04153 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T06:33:57Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0937af9bbfda43bdbf2d23f3c2d041532022-12-21T22:40:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.615375615375Obesity, Type 2 Diabetes, and Cancer RiskTiffany Scully0Abora Ettela1Derek LeRoith2Derek LeRoith3Emily Jane Gallagher4Emily Jane Gallagher5Division of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York City, NY, United StatesDivision of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York City, NY, United StatesDivision of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York City, NY, United StatesTisch Cancer Institute at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York City, NY, United StatesDivision of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York City, NY, United StatesTisch Cancer Institute at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York City, NY, United StatesObesity and type 2 diabetes have both been associated with increased cancer risk and are becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and dyslipidemia are associated with both obesity and type 2 diabetes and have been implicated in the obesity-cancer relationship. Multiple mechanisms have been proposed to link obesity and diabetes with cancer progression, including an increase in insulin/IGF-1 signaling, lipid and glucose uptake and metabolism, alterations in the profile of cytokines, chemokines, and adipokines, as well as changes in the adipose tissue directly adjacent to the cancer sites. This review aims to summarize and provide an update on the epidemiological and mechanistic evidence linking obesity and type 2 diabetes with cancer, focusing on the roles of insulin, lipids, and adipose tissue.https://www.frontiersin.org/articles/10.3389/fonc.2020.615375/fullobesityType 2 diabetescancerinsulinIGF-1lipids |
| spellingShingle | Tiffany Scully Abora Ettela Derek LeRoith Derek LeRoith Emily Jane Gallagher Emily Jane Gallagher Obesity, Type 2 Diabetes, and Cancer Risk Frontiers in Oncology obesity Type 2 diabetes cancer insulin IGF-1 lipids |
| title | Obesity, Type 2 Diabetes, and Cancer Risk |
| title_full | Obesity, Type 2 Diabetes, and Cancer Risk |
| title_fullStr | Obesity, Type 2 Diabetes, and Cancer Risk |
| title_full_unstemmed | Obesity, Type 2 Diabetes, and Cancer Risk |
| title_short | Obesity, Type 2 Diabetes, and Cancer Risk |
| title_sort | obesity type 2 diabetes and cancer risk |
| topic | obesity Type 2 diabetes cancer insulin IGF-1 lipids |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.615375/full |
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