Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients?
Abstract Objectives Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD). In the present study, we evaluated the inflammatory activity of the ascending aorta in RA patients who received biological treatment. Methods We assessed the aortic wall inflammation of RA...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-021-02585-w |
| _version_ | 1818884982691594240 |
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| author | D. A. M. Thuy Trang Koichi Okamura Takahito Suto Hideo Sakane Yukio Yonemoto Takahito Nakajima Yoshito Tsushima Hirotaka Chikuda |
| author_facet | D. A. M. Thuy Trang Koichi Okamura Takahito Suto Hideo Sakane Yukio Yonemoto Takahito Nakajima Yoshito Tsushima Hirotaka Chikuda |
| author_sort | D. A. M. Thuy Trang |
| collection | DOAJ |
| description | Abstract Objectives Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD). In the present study, we evaluated the inflammatory activity of the ascending aorta in RA patients who received biological treatment. Methods We assessed the aortic wall inflammation of RA patients using 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography before and after 6 months of biologic therapies. We also compared the inflammatory activity at the aortic wall in RA patients with remission or low disease activity (RLDA) and those with moderate or high disease activity (MHDA). The aortic uptake was measured by the standardized uptake value (SUV) and the target-to-background ratio (TBR). Results A total of 64 patients were included in the analysis (mean age, 58.4 ± 13.8 years old; female, 77%). The Disease Activity Score for 28 joints (DAS28) erythrocyte sedimentation rate (ESR) had significantly decreased after 6 months: from 5.0 ± 1.2 to 3.3 ± 1.2 (p < 0.001). The FDG uptake in the ascending aorta changed from baseline to 6 months, showing a maximum SUV (SUVmax) of 1.83 ± 0.34 to 1.90 ± 0.34 (p = 0.059) and TBR of 1.71 ± 0.23 to 1.75 ± 0.24 (p = 0.222). The SUVmax and TBR after 6 months were significantly higher in the RLDA group than in the MHDA group (2.05 ± 0.32 vs. 1.79 ± 0.33 (p = 0.002) and 1.89 ± 0.33 vs. 1.65 ± 0.20 (p = 0.001), respectively). The percentage of monocytes also significantly increased from baseline to 6 months: from 5.9 ± 1.6 to 6.9 ± 2.6 (p = 0.032). Conclusion The inflammation activity at the ascending aorta in RA patients did not change significantly after 6 months of biological treatment. RA patients with a low disease activity or in clinical remission after 6 months of biological treatment still had an increased inflammatory activity at the aortic wall. |
| first_indexed | 2024-12-19T15:58:12Z |
| format | Article |
| id | doaj.art-09387196d9c04009907ab5b026323019 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-19T15:58:12Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-09387196d9c04009907ab5b0263230192022-12-21T20:14:59ZengBMCArthritis Research & Therapy1478-63622021-08-012311710.1186/s13075-021-02585-wDo biologic therapies reduce aortic inflammation in rheumatoid arthritis patients?D. A. M. Thuy Trang0Koichi Okamura1Takahito Suto2Hideo Sakane3Yukio Yonemoto4Takahito Nakajima5Yoshito Tsushima6Hirotaka Chikuda7Department of Orthopaedic Surgery, Gunma University Graduate School of MedicineDepartment of Orthopaedic Surgery, Gunma University Graduate School of MedicineDepartment of Orthopaedic Surgery, Gunma University Graduate School of MedicineDepartment of Orthopaedic Surgery, Gunma University Graduate School of MedicineDepartment of Orthopaedic Surgery, Gunma University Graduate School of MedicineDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of MedicineDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of MedicineDepartment of Orthopaedic Surgery, Gunma University Graduate School of MedicineAbstract Objectives Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD). In the present study, we evaluated the inflammatory activity of the ascending aorta in RA patients who received biological treatment. Methods We assessed the aortic wall inflammation of RA patients using 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography before and after 6 months of biologic therapies. We also compared the inflammatory activity at the aortic wall in RA patients with remission or low disease activity (RLDA) and those with moderate or high disease activity (MHDA). The aortic uptake was measured by the standardized uptake value (SUV) and the target-to-background ratio (TBR). Results A total of 64 patients were included in the analysis (mean age, 58.4 ± 13.8 years old; female, 77%). The Disease Activity Score for 28 joints (DAS28) erythrocyte sedimentation rate (ESR) had significantly decreased after 6 months: from 5.0 ± 1.2 to 3.3 ± 1.2 (p < 0.001). The FDG uptake in the ascending aorta changed from baseline to 6 months, showing a maximum SUV (SUVmax) of 1.83 ± 0.34 to 1.90 ± 0.34 (p = 0.059) and TBR of 1.71 ± 0.23 to 1.75 ± 0.24 (p = 0.222). The SUVmax and TBR after 6 months were significantly higher in the RLDA group than in the MHDA group (2.05 ± 0.32 vs. 1.79 ± 0.33 (p = 0.002) and 1.89 ± 0.33 vs. 1.65 ± 0.20 (p = 0.001), respectively). The percentage of monocytes also significantly increased from baseline to 6 months: from 5.9 ± 1.6 to 6.9 ± 2.6 (p = 0.032). Conclusion The inflammation activity at the ascending aorta in RA patients did not change significantly after 6 months of biological treatment. RA patients with a low disease activity or in clinical remission after 6 months of biological treatment still had an increased inflammatory activity at the aortic wall.https://doi.org/10.1186/s13075-021-02585-wAortic inflammationFDG PET/CTBiologic therapyRheumatoid arthritis |
| spellingShingle | D. A. M. Thuy Trang Koichi Okamura Takahito Suto Hideo Sakane Yukio Yonemoto Takahito Nakajima Yoshito Tsushima Hirotaka Chikuda Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients? Arthritis Research & Therapy Aortic inflammation FDG PET/CT Biologic therapy Rheumatoid arthritis |
| title | Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients? |
| title_full | Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients? |
| title_fullStr | Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients? |
| title_full_unstemmed | Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients? |
| title_short | Do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients? |
| title_sort | do biologic therapies reduce aortic inflammation in rheumatoid arthritis patients |
| topic | Aortic inflammation FDG PET/CT Biologic therapy Rheumatoid arthritis |
| url | https://doi.org/10.1186/s13075-021-02585-w |
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