Quantifying mechanical force in axonal growth and guidance
Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00359/full |
| _version_ | 1818196708368056320 |
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| author | Ahmad Ibrahim Mahmoud Athamneh Daniel Marcel Suter |
| author_facet | Ahmad Ibrahim Mahmoud Athamneh Daniel Marcel Suter |
| author_sort | Ahmad Ibrahim Mahmoud Athamneh |
| collection | DOAJ |
| description | Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial synaptic connections. However, much of the details about the exact role of force in these fundamental processes remain unknown. In this review, we highlight (1) standing questions concerning the role of mechanical force in axonal growth and guidance and (2) different experimental techniques used to quantify forces in axons and growth cones. We believe that satisfying answers to these questions will require quantitative information about the relationship between elongation, forces, cytoskeletal dynamics, axonal transport, signaling, substrate adhesion, and stiffness contributing to directional growth advance. Furthermore, we address why a wide range of force values have been reported in the literature, and what these values mean in the context of neuronal mechanics. We hope that this review will provide a guide for those interested in studying the role of force in development and regeneration of neuronal networks. |
| first_indexed | 2024-12-12T01:38:22Z |
| format | Article |
| id | doaj.art-0938be176bbd44af994d97f894143f80 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T01:38:22Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-0938be176bbd44af994d97f894143f802022-12-22T00:42:47ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-09-01910.3389/fncel.2015.00359153071Quantifying mechanical force in axonal growth and guidanceAhmad Ibrahim Mahmoud Athamneh0Daniel Marcel Suter1Purdue UniversityPurdue UniversityMechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial synaptic connections. However, much of the details about the exact role of force in these fundamental processes remain unknown. In this review, we highlight (1) standing questions concerning the role of mechanical force in axonal growth and guidance and (2) different experimental techniques used to quantify forces in axons and growth cones. We believe that satisfying answers to these questions will require quantitative information about the relationship between elongation, forces, cytoskeletal dynamics, axonal transport, signaling, substrate adhesion, and stiffness contributing to directional growth advance. Furthermore, we address why a wide range of force values have been reported in the literature, and what these values mean in the context of neuronal mechanics. We hope that this review will provide a guide for those interested in studying the role of force in development and regeneration of neuronal networks.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00359/fullBiophysicsCytoskeletonMechanotransductiontraction forceAxon elongationGrowth cone biomechanics |
| spellingShingle | Ahmad Ibrahim Mahmoud Athamneh Daniel Marcel Suter Quantifying mechanical force in axonal growth and guidance Frontiers in Cellular Neuroscience Biophysics Cytoskeleton Mechanotransduction traction force Axon elongation Growth cone biomechanics |
| title | Quantifying mechanical force in axonal growth and guidance |
| title_full | Quantifying mechanical force in axonal growth and guidance |
| title_fullStr | Quantifying mechanical force in axonal growth and guidance |
| title_full_unstemmed | Quantifying mechanical force in axonal growth and guidance |
| title_short | Quantifying mechanical force in axonal growth and guidance |
| title_sort | quantifying mechanical force in axonal growth and guidance |
| topic | Biophysics Cytoskeleton Mechanotransduction traction force Axon elongation Growth cone biomechanics |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00359/full |
| work_keys_str_mv | AT ahmadibrahimmahmoudathamneh quantifyingmechanicalforceinaxonalgrowthandguidance AT danielmarcelsuter quantifyingmechanicalforceinaxonalgrowthandguidance |