DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion
Several mechanisms have been associated with transcriptional and post-transcriptional regulation of PD-L1 in cancer. Here the authors show that a RNA binding protein, DENR, positively regulates the translation of JAK2 and induces PD-L1 expression in tumor cells, associated with immune evasion.
Bibliographic Details
| Main Authors: |
Baiwen Chen,
Jiajia Hu,
Xianting Hu,
Huifang Chen,
Rujuan Bao,
Yatao Zhou,
Youqiong Ye,
Meixiao Zhan,
Wei Cai,
Huabin Li,
Hua-Bing Li |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-29754-y
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