The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus
Background. Diabetic macular edema (DME) is a severe complication of type 2 diabetes mellitus (DM) and a leading cause of vision loss in the working age population of most developed countries. The gold standard for DME treatment should be based on a good control of glycemia along with control of lip...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2019-02-01
|
| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
| Subjects: | |
| Online Access: | http://iej.zaslavsky.com.ua/article/view/158686 |
| _version_ | 1819004062402609152 |
|---|---|
| author | M.L. Kyryliuk S.А. Suk S.O. Rykov S.Yu. Mogilevskyy |
| author_facet | M.L. Kyryliuk S.А. Suk S.O. Rykov S.Yu. Mogilevskyy |
| author_sort | M.L. Kyryliuk |
| collection | DOAJ |
| description | Background. Diabetic macular edema (DME) is a severe complication of type 2 diabetes mellitus (DM) and a leading cause of vision loss in the working age population of most developed countries. The gold standard for DME treatment should be based on a good control of glycemia along with control of lipids and renal function. However, despite the systemic metabolic control values being essential for patients with diabetic retinopathy, it has proven to be insufficient for DME if it appears. In these patients, additional measures are needed in order to avoid the subsequent loss of vision. The aim of the work was to assess the content of blood fractalkine in patients with type 2 DM and DME in conjunction with the indicators of the thickness of the macula layers. Materials and methods. The study involved 82 patients with type 2 DM (145 eyes), divided into 4 groups in accordance with the DME form. The average age of patients was 65.25 ± 10.85 years, the average duration of DM — 14.00 ± 7.05 years, the average level of HbA1c — 8.40 ± 1.58 %. Results. Using analysis of variance and regression analysis, methods for constructing logistic regression models, we have shown that fractalkine is not associated with the risk of not low values (> QI) of nerve fiber layer, ganglion cell layer, inner plexiform layer, central sector of macula, thickness of fovea. Conclusions. Fractalkine may be a promising new therapeutic method for the treatment of diabetic retinal diseases. DME tends to be a chronic disease, although spontaneous recovery is not uncommon. It is important to recognize that 35 % of patients with macular edema had spontaneous resolution after 6 months if untreated. |
| first_indexed | 2024-12-20T23:30:55Z |
| format | Article |
| id | doaj.art-093b029792674eb1bc51b7f29a03268c |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-12-20T23:30:55Z |
| publishDate | 2019-02-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-093b029792674eb1bc51b7f29a03268c2022-12-21T19:23:17ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272019-02-01151101510.22141/2224-0721.15.1.2019.158686158686The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitusM.L. Kyryliuk0S.А. Suk1S.O. Rykov2S.Yu. Mogilevskyy3Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine / Kyiv Clinical Ophthalmologic Hospital, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, UkraineBackground. Diabetic macular edema (DME) is a severe complication of type 2 diabetes mellitus (DM) and a leading cause of vision loss in the working age population of most developed countries. The gold standard for DME treatment should be based on a good control of glycemia along with control of lipids and renal function. However, despite the systemic metabolic control values being essential for patients with diabetic retinopathy, it has proven to be insufficient for DME if it appears. In these patients, additional measures are needed in order to avoid the subsequent loss of vision. The aim of the work was to assess the content of blood fractalkine in patients with type 2 DM and DME in conjunction with the indicators of the thickness of the macula layers. Materials and methods. The study involved 82 patients with type 2 DM (145 eyes), divided into 4 groups in accordance with the DME form. The average age of patients was 65.25 ± 10.85 years, the average duration of DM — 14.00 ± 7.05 years, the average level of HbA1c — 8.40 ± 1.58 %. Results. Using analysis of variance and regression analysis, methods for constructing logistic regression models, we have shown that fractalkine is not associated with the risk of not low values (> QI) of nerve fiber layer, ganglion cell layer, inner plexiform layer, central sector of macula, thickness of fovea. Conclusions. Fractalkine may be a promising new therapeutic method for the treatment of diabetic retinal diseases. DME tends to be a chronic disease, although spontaneous recovery is not uncommon. It is important to recognize that 35 % of patients with macular edema had spontaneous resolution after 6 months if untreated.http://iej.zaslavsky.com.ua/article/view/158686diabetes mellitusfractalkinediabetic macular edema |
| spellingShingle | M.L. Kyryliuk S.А. Suk S.O. Rykov S.Yu. Mogilevskyy The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus Mìžnarodnij Endokrinologìčnij Žurnal diabetes mellitus fractalkine diabetic macular edema |
| title | The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus |
| title_full | The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus |
| title_fullStr | The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus |
| title_full_unstemmed | The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus |
| title_short | The role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus |
| title_sort | role of fractalkine in the development of diabetic macular edema in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus fractalkine diabetic macular edema |
| url | http://iej.zaslavsky.com.ua/article/view/158686 |
| work_keys_str_mv | AT mlkyryliuk theroleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT sasuk theroleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT sorykov theroleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT syumogilevskyy theroleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT mlkyryliuk roleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT sasuk roleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT sorykov roleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus AT syumogilevskyy roleoffractalkineinthedevelopmentofdiabeticmacularedemainpatientswithtype2diabetesmellitus |