Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis
<p>Abstract</p> <p>Background</p> <p>This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) with chest high-resolution computed tomography (HRCT) for the rapid diagnosis of active pulmonary tuberculosis (PTB) in patients suspected of P...
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/12/141 |
| _version_ | 1811284522128375808 |
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| author | Shin Jung Chang Yoon Kim Tae Kim Hyung Ahn Chul Byun Min |
| author_facet | Shin Jung Chang Yoon Kim Tae Kim Hyung Ahn Chul Byun Min |
| author_sort | Shin Jung |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) with chest high-resolution computed tomography (HRCT) for the rapid diagnosis of active pulmonary tuberculosis (PTB) in patients suspected of PTB but found to have a negative sputum acid-fast bacilli (AFB) smear.</p> <p>Methods</p> <p>We evaluated the diagnostic accuracy of results from FOB and HRCT in 126 patients at Gangnam Severance Hospital (Seoul, Korea) who were suspected of having PTB.</p> <p>Results</p> <p>Of 126 patients who had negative sputum AFB smears but were suspected of having PTB, 54 patients were confirmed as having active PTB. Hemoptysis was negatively correlated with active PTB. Tree-in-bud appearance on HRCT was significantly associated with active PTB. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FOB alone was 75.9%, 97.2%, 95.3%, and 84.3%, respectively, for the rapid diagnosis of active PTB. The combination of FOB and HRCT improved the sensitivity to 96.3% and the NPV to 96.2%.</p> <p>Conclusions</p> <p>FOB is a useful tool in the rapid diagnosis of active PTB with a high sensitivity, specificity, PPV and NPV in sputum smear-negative PTB-suspected patients. HRCT improves the sensitivity of FOB when used in combination with FOB in sputum smear-negative patients suspected of having PTB.</p> |
| first_indexed | 2024-04-13T02:30:51Z |
| format | Article |
| id | doaj.art-093d07b2f79c481da416edbee24605f4 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T02:30:51Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-093d07b2f79c481da416edbee24605f42022-12-22T03:06:35ZengBMCBMC Infectious Diseases1471-23342012-06-0112114110.1186/1471-2334-12-141Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosisShin JungChang YoonKim TaeKim HyungAhn ChulByun Min<p>Abstract</p> <p>Background</p> <p>This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) with chest high-resolution computed tomography (HRCT) for the rapid diagnosis of active pulmonary tuberculosis (PTB) in patients suspected of PTB but found to have a negative sputum acid-fast bacilli (AFB) smear.</p> <p>Methods</p> <p>We evaluated the diagnostic accuracy of results from FOB and HRCT in 126 patients at Gangnam Severance Hospital (Seoul, Korea) who were suspected of having PTB.</p> <p>Results</p> <p>Of 126 patients who had negative sputum AFB smears but were suspected of having PTB, 54 patients were confirmed as having active PTB. Hemoptysis was negatively correlated with active PTB. Tree-in-bud appearance on HRCT was significantly associated with active PTB. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FOB alone was 75.9%, 97.2%, 95.3%, and 84.3%, respectively, for the rapid diagnosis of active PTB. The combination of FOB and HRCT improved the sensitivity to 96.3% and the NPV to 96.2%.</p> <p>Conclusions</p> <p>FOB is a useful tool in the rapid diagnosis of active PTB with a high sensitivity, specificity, PPV and NPV in sputum smear-negative PTB-suspected patients. HRCT improves the sensitivity of FOB when used in combination with FOB in sputum smear-negative patients suspected of having PTB.</p>http://www.biomedcentral.com/1471-2334/12/141 |
| spellingShingle | Shin Jung Chang Yoon Kim Tae Kim Hyung Ahn Chul Byun Min Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis BMC Infectious Diseases |
| title | Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis |
| title_full | Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis |
| title_fullStr | Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis |
| title_full_unstemmed | Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis |
| title_short | Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis |
| title_sort | fiberoptic bronchoscopy for the rapid diagnosis of smear negative pulmonary tuberculosis |
| url | http://www.biomedcentral.com/1471-2334/12/141 |
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