Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers
Despite the commendable milestones achieved in molecular maxillofacial pathology in the last decade, there remains a paucity of utilization of ancillary nanomolecular tools that complement the omics-based approaches. As the advent of omics science transforms our understanding of tumour biology from...
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Elsevier
2020-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020317333 |
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| author | Henry A. Adeola Saheed Sabiu Tayo A. Adekiya Raphael T. Aruleba Christiana E. Aruwa Babatunji E. Oyinloye |
| author_facet | Henry A. Adeola Saheed Sabiu Tayo A. Adekiya Raphael T. Aruleba Christiana E. Aruwa Babatunji E. Oyinloye |
| author_sort | Henry A. Adeola |
| collection | DOAJ |
| description | Despite the commendable milestones achieved in molecular maxillofacial pathology in the last decade, there remains a paucity of utilization of ancillary nanomolecular tools that complement the omics-based approaches. As the advent of omics science transforms our understanding of tumour biology from a phenomenological to a complex network (systems-oriented) paradigm, several ancillary tools have emerged to improve the scope of individualized medicine. Targeted nano drug delivery systems have significantly reduced toxicity of chemotherapeutic agents in a precise manner. Many conventional cancer therapies are limited in efficacy and this has led to the emergence of nanomedical innovations. Despite the success of nanomedicine, a major challenge that persists is tumour heterogeneity and biological complexity. A good understanding of the interaction between inorganic nanoparticles and the biological systems has led to the development of better tools for individualized medicine. Tools such as the composite organic-inorganic nanoparticles (COINs) and the quantum dots (QD) have significantly improved the identification and quantification of disease biomarkers, histopathological detection methods, as well as improving the clinical translation and utility of these nanomaterials. Nanomedicine has lent credence to several multipronged theranostic applications in medicine, and this has improved the medical practice tremendously. Despite the palpable influence of nanomedicine on the delivery of individualized medical therapies, the term “nanodentistry” remains in the background without much hype, albeit some progress has been made in this area. Hence, this review discusses the potential and challenges of nanodentistry in the diagnosis and treatment of maxillofacial pathologies, particularly cancer in resource-limited settings. |
| first_indexed | 2024-12-19T14:17:10Z |
| format | Article |
| id | doaj.art-093f809aaef6429493e3b31457812294 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-19T14:17:10Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-093f809aaef6429493e3b314578122942022-12-21T20:17:57ZengElsevierHeliyon2405-84402020-09-0169e04890Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancersHenry A. Adeola0Saheed Sabiu1Tayo A. Adekiya2Raphael T. Aruleba3Christiana E. Aruwa4Babatunji E. Oyinloye5Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, University of the Western Cape and Tygerberg Hospital, Cape Town South Africa; Division of Dermatology, Department of Medicine, Faculty of Health Sciences and Groote Schuur Hospital, University of Cape Town, Cape Town South Africa; Corresponding author.Department of Biotechnology and Food Technology, Durban University of Technology, Steve Biko Campus, Steve Biko Road, Berea, Durban 4001, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South AfricaDepartment of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town 7701, South AfricaDepartment of Biotechnology and Food Technology, Durban University of Technology, Steve Biko Campus, Steve Biko Road, Berea, Durban 4001, South AfricaPhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, Faculty of Sciences, Afe Babalola University, P.M.B 5454 Ado Ekiti 360001, NigeriaDespite the commendable milestones achieved in molecular maxillofacial pathology in the last decade, there remains a paucity of utilization of ancillary nanomolecular tools that complement the omics-based approaches. As the advent of omics science transforms our understanding of tumour biology from a phenomenological to a complex network (systems-oriented) paradigm, several ancillary tools have emerged to improve the scope of individualized medicine. Targeted nano drug delivery systems have significantly reduced toxicity of chemotherapeutic agents in a precise manner. Many conventional cancer therapies are limited in efficacy and this has led to the emergence of nanomedical innovations. Despite the success of nanomedicine, a major challenge that persists is tumour heterogeneity and biological complexity. A good understanding of the interaction between inorganic nanoparticles and the biological systems has led to the development of better tools for individualized medicine. Tools such as the composite organic-inorganic nanoparticles (COINs) and the quantum dots (QD) have significantly improved the identification and quantification of disease biomarkers, histopathological detection methods, as well as improving the clinical translation and utility of these nanomaterials. Nanomedicine has lent credence to several multipronged theranostic applications in medicine, and this has improved the medical practice tremendously. Despite the palpable influence of nanomedicine on the delivery of individualized medical therapies, the term “nanodentistry” remains in the background without much hype, albeit some progress has been made in this area. Hence, this review discusses the potential and challenges of nanodentistry in the diagnosis and treatment of maxillofacial pathologies, particularly cancer in resource-limited settings.http://www.sciencedirect.com/science/article/pii/S2405844020317333Materials scienceDentistryBiomedical engineeringCancerNanodentistryPrecision dentistry |
| spellingShingle | Henry A. Adeola Saheed Sabiu Tayo A. Adekiya Raphael T. Aruleba Christiana E. Aruwa Babatunji E. Oyinloye Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers Heliyon Materials science Dentistry Biomedical engineering Cancer Nanodentistry Precision dentistry |
| title | Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers |
| title_full | Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers |
| title_fullStr | Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers |
| title_full_unstemmed | Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers |
| title_short | Prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers |
| title_sort | prospects of nanodentistry for the diagnosis and treatment of maxillofacial pathologies and cancers |
| topic | Materials science Dentistry Biomedical engineering Cancer Nanodentistry Precision dentistry |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020317333 |
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