<i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature
<i>Paecilomyces</i>/<i>Purpureocillium</i> has recently been recognized as an emerging human pathogen, causing serious infection in immunocompromised and immunocompetent patients. Several predisposing factors have been reported, including foreign body implants, previous surge...
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| 格式: | Article |
| 語言: | English |
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MDPI AG
2022-09-01
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| 叢編: | Journal of Fungi |
| 主題: | |
| 在線閱讀: | https://www.mdpi.com/2309-608X/8/9/930 |
| _version_ | 1827659835948138496 |
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| author | Musaed Alharbi Nourah Alruqaie Ahmed Alzahrani Maha Almuneef |
| author_facet | Musaed Alharbi Nourah Alruqaie Ahmed Alzahrani Maha Almuneef |
| author_sort | Musaed Alharbi |
| collection | DOAJ |
| description | <i>Paecilomyces</i>/<i>Purpureocillium</i> has recently been recognized as an emerging human pathogen, causing serious infection in immunocompromised and immunocompetent patients. Several predisposing factors have been reported, including foreign body implants, previous surgery, or trauma. Treatment with antifungal drugs often fails as species-specific differences in antifungal susceptibilities are one of the management challenges. Surgical debridement with or without antifungal therapy was sufficient to cure the infection in a few reported cases. Nonetheless, the surgical approach has been found to decrease the chance of dissemination and recurrence. Here, we report the first pediatric patient with chronic osteomyelitis of the femur secondary to <i>Paecilomyces</i> species, with no predisposing risk factors. Our case was successfully treated with a combination of antifungal therapy and surgical debridement. Additionally, we describe the first extensive literature review of previously reported <i>Paecilomyces</i>/<i>Purpureocillium</i> species infections in pediatric age groups. |
| first_indexed | 2024-03-09T23:30:50Z |
| format | Article |
| id | doaj.art-093fd5d2d22f4f898f3d2f7776b4e739 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T23:30:50Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-093fd5d2d22f4f898f3d2f7776b4e7392023-11-23T17:09:26ZengMDPI AGJournal of Fungi2309-608X2022-09-018993010.3390/jof8090930<i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the LiteratureMusaed Alharbi0Nourah Alruqaie1Ahmed Alzahrani2Maha Almuneef3Department of Pediatric Infectious Diseases, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh P.O. Box. 22490, Saudi ArabiaDepartment of Pediatric Infectious Diseases, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh P.O. Box. 22490, Saudi ArabiaKing Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh P.O. Box. 22490, Saudi ArabiaDepartment of Pediatric Infectious Diseases, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh P.O. Box. 22490, Saudi Arabia<i>Paecilomyces</i>/<i>Purpureocillium</i> has recently been recognized as an emerging human pathogen, causing serious infection in immunocompromised and immunocompetent patients. Several predisposing factors have been reported, including foreign body implants, previous surgery, or trauma. Treatment with antifungal drugs often fails as species-specific differences in antifungal susceptibilities are one of the management challenges. Surgical debridement with or without antifungal therapy was sufficient to cure the infection in a few reported cases. Nonetheless, the surgical approach has been found to decrease the chance of dissemination and recurrence. Here, we report the first pediatric patient with chronic osteomyelitis of the femur secondary to <i>Paecilomyces</i> species, with no predisposing risk factors. Our case was successfully treated with a combination of antifungal therapy and surgical debridement. Additionally, we describe the first extensive literature review of previously reported <i>Paecilomyces</i>/<i>Purpureocillium</i> species infections in pediatric age groups.https://www.mdpi.com/2309-608X/8/9/930<i>Paecilomyces</i><i>Purpureocillium</i>fungalosteomyelitispediatricimmunocompetent |
| spellingShingle | Musaed Alharbi Nourah Alruqaie Ahmed Alzahrani Maha Almuneef <i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature Journal of Fungi <i>Paecilomyces</i> <i>Purpureocillium</i> fungal osteomyelitis pediatric immunocompetent |
| title | <i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature |
| title_full | <i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature |
| title_fullStr | <i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature |
| title_full_unstemmed | <i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature |
| title_short | <i>Paecilomyces</i>/<i>Purpureocillium</i> Infection in Children, Case Report, and Review of the Literature |
| title_sort | i paecilomyces i i purpureocillium i infection in children case report and review of the literature |
| topic | <i>Paecilomyces</i> <i>Purpureocillium</i> fungal osteomyelitis pediatric immunocompetent |
| url | https://www.mdpi.com/2309-608X/8/9/930 |
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