Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals
Introduction : Hypertension is a complex disease in which a significant interaction between genetic and environmental factors takes place. The renin–angiotensin system plays an important role regulating blood pressure to maintain homeostasis and vascular tone. In the present work, the role of angiot...
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| Format: | Article |
| Language: | English |
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SAGE Publications
2012-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320311419175 |
| _version_ | 1797285376425984000 |
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| author | Nancy Martínez-Rodríguez Carlos Posadas-Romero Guillermo Cardoso José Manuel Pérez-Rodríguez Nonanzit Pérez-Hernández Maite Vallejo Gilberto Vargas-Alarcón |
| author_facet | Nancy Martínez-Rodríguez Carlos Posadas-Romero Guillermo Cardoso José Manuel Pérez-Rodríguez Nonanzit Pérez-Hernández Maite Vallejo Gilberto Vargas-Alarcón |
| author_sort | Nancy Martínez-Rodríguez |
| collection | DOAJ |
| description | Introduction : Hypertension is a complex disease in which a significant interaction between genetic and environmental factors takes place. The renin–angiotensin system plays an important role regulating blood pressure to maintain homeostasis and vascular tone. In the present work, the role of angiotensin II type 1-receptor (AGTR1) gene polymorphisms as susceptibility markers for hypertension was evaluated. Materials and methods : Five polymorphisms in the AGTR1 gene were genotyped by 5′ exonuclease TaqMan genotyping assays in 239 hypertensive and 371 non-hypertensive individuals. Results : A similar distribution of rs275651, rs275652, rs275653, and rs5183 polymorphisms was observed in both studied groups. Different distribution of rs5182 genotypes was observed between the studied groups ( p = 0.016). According to the co-dominant model, individuals with rs5182 CC genotype have a 1.83-fold increased risk of developing hypertension ( p = 0.009). Polymorphisms were distributed in two blocks: block 1 included the rs275651, rs275652, and rs275653 polymorphisms, whereas block 2 included the rs5183 and rs5182 polymorphisms. Individuals with hypertension showed increased frequency of ‘ CA ’ haplotype of block 2 when compared to non-hypertensive individuals ( p = 0.015, odds ratio = 1.33). Conclusion : The results suggest that the rs5182 gene polymorphism could be involved in the risk of developing hypertension in Mexican individuals. |
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| id | doaj.art-0940c3497dbb422f9e3041f1b991c33f |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:02:15Z |
| publishDate | 2012-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-0940c3497dbb422f9e3041f1b991c33f2024-03-02T10:28:07ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762012-03-011310.1177/1470320311419175Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individualsNancy Martínez-Rodríguez0Carlos Posadas-Romero1Guillermo Cardoso2José Manuel Pérez-Rodríguez3Nonanzit Pérez-Hernández4Maite Vallejo5Gilberto Vargas-Alarcón6Graduate Studies in Biomedical Sciences, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoSociomedical Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoIntroduction : Hypertension is a complex disease in which a significant interaction between genetic and environmental factors takes place. The renin–angiotensin system plays an important role regulating blood pressure to maintain homeostasis and vascular tone. In the present work, the role of angiotensin II type 1-receptor (AGTR1) gene polymorphisms as susceptibility markers for hypertension was evaluated. Materials and methods : Five polymorphisms in the AGTR1 gene were genotyped by 5′ exonuclease TaqMan genotyping assays in 239 hypertensive and 371 non-hypertensive individuals. Results : A similar distribution of rs275651, rs275652, rs275653, and rs5183 polymorphisms was observed in both studied groups. Different distribution of rs5182 genotypes was observed between the studied groups ( p = 0.016). According to the co-dominant model, individuals with rs5182 CC genotype have a 1.83-fold increased risk of developing hypertension ( p = 0.009). Polymorphisms were distributed in two blocks: block 1 included the rs275651, rs275652, and rs275653 polymorphisms, whereas block 2 included the rs5183 and rs5182 polymorphisms. Individuals with hypertension showed increased frequency of ‘ CA ’ haplotype of block 2 when compared to non-hypertensive individuals ( p = 0.015, odds ratio = 1.33). Conclusion : The results suggest that the rs5182 gene polymorphism could be involved in the risk of developing hypertension in Mexican individuals.https://doi.org/10.1177/1470320311419175 |
| spellingShingle | Nancy Martínez-Rodríguez Carlos Posadas-Romero Guillermo Cardoso José Manuel Pérez-Rodríguez Nonanzit Pérez-Hernández Maite Vallejo Gilberto Vargas-Alarcón Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals Journal of the Renin-Angiotensin-Aldosterone System |
| title | Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals |
| title_full | Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals |
| title_fullStr | Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals |
| title_full_unstemmed | Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals |
| title_short | Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals |
| title_sort | association of angiotensin ii type 1 receptor gene polymorphisms with the risk of developing hypertension in mexican individuals |
| url | https://doi.org/10.1177/1470320311419175 |
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