miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy
Breast cancer is one of the most commonly diagnosed cancer types worldwide. Regarding molecular characteristics and classification, it is a heterogeneous disease, which makes it more challenging to diagnose. As is commonly known, early detection plays a pivotal role in decreasing mortality and provi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/12/595 |
| _version_ | 1797381571154542592 |
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| author | Iga Dziechciowska Małgorzata Dąbrowska Anna Mizielska Natalia Pyra Natalia Lisiak Przemysław Kopczyński Magdalena Jankowska-Wajda Błażej Rubiś |
| author_facet | Iga Dziechciowska Małgorzata Dąbrowska Anna Mizielska Natalia Pyra Natalia Lisiak Przemysław Kopczyński Magdalena Jankowska-Wajda Błażej Rubiś |
| author_sort | Iga Dziechciowska |
| collection | DOAJ |
| description | Breast cancer is one of the most commonly diagnosed cancer types worldwide. Regarding molecular characteristics and classification, it is a heterogeneous disease, which makes it more challenging to diagnose. As is commonly known, early detection plays a pivotal role in decreasing mortality and providing a better prognosis for all patients. Different treatment strategies can be adjusted based on tumor progression and molecular characteristics, including personalized therapies. However, dealing with resistance to drugs and recurrence is a challenge. The therapeutic options are limited and can still lead to poor clinical outcomes. This review aims to shed light on the current perspective on the role of miRNAs in breast cancer diagnostics, characteristics, and prognosis. We discuss the potential role of selected non-coding RNAs most commonly associated with breast cancer. These include miR-21, miR-106a, miR-155, miR-141, let-7c, miR-335, miR-126, miR-199a, miR-101, and miR-9, which are perceived as potential biomarkers in breast cancer prognosis, diagnostics, and treatment response monitoring. As miRNAs differ in expression levels in different types of cancer, they may provide novel cancer therapy strategies. However, some limitations regarding dynamic alterations, tissue-specific profiles, and detection methods must also be raised. |
| first_indexed | 2024-03-08T20:53:21Z |
| format | Article |
| id | doaj.art-0943223ab0874a30b60680a90c618ca9 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-08T20:53:21Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-0943223ab0874a30b60680a90c618ca92023-12-22T14:00:37ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-11-0145129500952510.3390/cimb45120595miRNA Expression Profiling in Human Breast Cancer Diagnostics and TherapyIga Dziechciowska0Małgorzata Dąbrowska1Anna Mizielska2Natalia Pyra3Natalia Lisiak4Przemysław Kopczyński5Magdalena Jankowska-Wajda6Błażej Rubiś7Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandCentre for Orthodontic Mini-Implants, Department and Clinic of Maxillofacial Orthopedics and Orthodontics, Poznan University of Medical Sciences, Bukowska 70 Str., 60-812 Poznan, PolandFaculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8 Str., 61-614 Poznan, PolandDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandBreast cancer is one of the most commonly diagnosed cancer types worldwide. Regarding molecular characteristics and classification, it is a heterogeneous disease, which makes it more challenging to diagnose. As is commonly known, early detection plays a pivotal role in decreasing mortality and providing a better prognosis for all patients. Different treatment strategies can be adjusted based on tumor progression and molecular characteristics, including personalized therapies. However, dealing with resistance to drugs and recurrence is a challenge. The therapeutic options are limited and can still lead to poor clinical outcomes. This review aims to shed light on the current perspective on the role of miRNAs in breast cancer diagnostics, characteristics, and prognosis. We discuss the potential role of selected non-coding RNAs most commonly associated with breast cancer. These include miR-21, miR-106a, miR-155, miR-141, let-7c, miR-335, miR-126, miR-199a, miR-101, and miR-9, which are perceived as potential biomarkers in breast cancer prognosis, diagnostics, and treatment response monitoring. As miRNAs differ in expression levels in different types of cancer, they may provide novel cancer therapy strategies. However, some limitations regarding dynamic alterations, tissue-specific profiles, and detection methods must also be raised.https://www.mdpi.com/1467-3045/45/12/595breast cancermiRNA profilingcancer diagnosticscancer therapy |
| spellingShingle | Iga Dziechciowska Małgorzata Dąbrowska Anna Mizielska Natalia Pyra Natalia Lisiak Przemysław Kopczyński Magdalena Jankowska-Wajda Błażej Rubiś miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy Current Issues in Molecular Biology breast cancer miRNA profiling cancer diagnostics cancer therapy |
| title | miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy |
| title_full | miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy |
| title_fullStr | miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy |
| title_full_unstemmed | miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy |
| title_short | miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy |
| title_sort | mirna expression profiling in human breast cancer diagnostics and therapy |
| topic | breast cancer miRNA profiling cancer diagnostics cancer therapy |
| url | https://www.mdpi.com/1467-3045/45/12/595 |
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