LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression

LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression

Abstract Background LATS1/2 are frequently mutated and down-regulated in endometrial cancer (EC), but the contributions of LATS1/2 in EC progression remains unclear. Impaired antigen presentation due to mutations or downregulation of the major histocompatibility complex class I (MHC-I) has been impl...

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Bibliographic Details
Main Authors: Qianlan Yang, Zehen Lv, Mengfei Wang, Mengwen Kong, Cheng Zhong, Kun Gao, Xiaoping Wan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Endometrial cancer
Immune evasion
MHC-I
LATS1/2
STAT1
Online Access:https://doi.org/10.1186/s13046-024-02979-z

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