Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients
Background and aim: Malnutrition is one of the most troublesome comorbidities among hemodialysis patients (HD). Myostatin (MSTN) belongs to the transforming growth factor-β superfamily. In HD patients, MSTN effects are not limited to skeletal muscle growth. The present study aimed to assess MSTN le...
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PAGEPress Publications
2023-12-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | https://www.pagepressjournals.org/index.php/aiua/article/view/11869 |
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| author | Amal H. Ibrahim Sammar A. Kasim Alshimaa A. Ezzat Noha E. Ibrahim Donia A. Hassan Amira Sh. Ibrahim Tamer A. Abouelgreed Ehab M. Abdo Naglaa M. Aboelsoud Nermeen M. Abdelmonem Mohammad Thabet Alnajem Ahmed A. Aboomar |
| author_facet | Amal H. Ibrahim Sammar A. Kasim Alshimaa A. Ezzat Noha E. Ibrahim Donia A. Hassan Amira Sh. Ibrahim Tamer A. Abouelgreed Ehab M. Abdo Naglaa M. Aboelsoud Nermeen M. Abdelmonem Mohammad Thabet Alnajem Ahmed A. Aboomar |
| author_sort | Amal H. Ibrahim |
| collection | DOAJ |
| description |
Background and aim: Malnutrition is one of the most troublesome comorbidities among hemodialysis patients (HD). Myostatin (MSTN) belongs to the transforming growth factor-β superfamily. In HD patients, MSTN effects are not limited to skeletal muscle growth. The present study aimed to assess MSTN levels in HD patients and its relation to various clinical and biochemical parameters. Patients and methods: The present case control study included 60 patients on HD for at least three years. In addition, there were age and sex-matched healthy subjects who constitutes the control group. Nutritional status was evaluated using the malnutrition inflammation score (MIS). Muscle wasting in the present study was evaluated using the lean tissue index (LTI) as assessed by the body composition monitor (BCM). Rectus Femoris Muscle (RFM) thickness was also measured as indicator for nutritional status of patient. Results: The present study included 60 HD patients, and ageand sex-matched healthy controls. Patients expressed significantly higher myostatin levels when compared to controls [median (IQR): 221.3 (153.5-688.2) versus 144.8 (97.0-281.7), p < 0.001]. According to MIS, patients were classified into those with no/mild malnutrition (n = 22) and others with moderate/severe malnutrition (n = 38). Comparison between the two subgroups revealed that the former group had significantly lower myostatin levels [167.7 (150.3-236.3) versus 341.7 (160.9-955.9), p = 0.004]. According to LTI, patients were classified into those with muscle wasting (n = 23) and others without muscle wasting (n = 37). Comparative analysis showed that patients in the former group had significantly higher myostatin levels [775.1 (325.1-2133.7) versus 161.8 (142.6-302.3), p < 0.001]. Conclusions: Myostatin seems to be a promising marker for identification of malnutrition and muscle wasting in HD patients.
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| first_indexed | 2024-03-08T21:34:51Z |
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| language | English |
| last_indexed | 2024-03-08T21:34:51Z |
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| spelling | doaj.art-0943bb8b47fb44f2b39dd7e5f19c39d02023-12-20T23:06:41ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972023-12-0110.4081/aiua.2023.11869Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patientsAmal H. Ibrahim 0Sammar A. Kasim1Alshimaa A. Ezzat 2Noha E. Ibrahim3Donia A. Hassan4Amira Sh. Ibrahim5Tamer A. Abouelgreed6Ehab M. Abdo7Naglaa M. Aboelsoud8Nermeen M. Abdelmonem9Mohammad Thabet Alnajem 10Ahmed A. Aboomar11Department of Internal Medicine, Nephrology Unit, Al-Azhar University, CairoDepartment of Internal Medicine, Nephrology Unit, Al-Azhar University, CairoDepartment of Radiology, Faculty of Medicine, Al-Azhar University, CairoDepartment of Microbial Biotechnology, Biotechnology Research Institute, National Research Centre (NRC), GizaDepartment of Clinical Pathology, Al-Azhar University, CairoDepartment of Rheumatology and Rehabilitation, Faculty of Medicine for girls, Al-Azhar University, CairoDepartment of Urology, Faculty of Medicine, Al-Azhar University, CairoDepartment of Vascular Surgery, Faculty of Medicine, Al-Azhar University, CairoDepartment of Radiology, Faculty of Medicine, Al-Azhar University, CairoDepartment of Radiology, Thumbay University Hospital, AjmanDepartment of Radiology, Tawam Hospital, AlainDepartment of internal medicine, Nephrology Unit, Faculty Medicine, Tanta University, Tanta Background and aim: Malnutrition is one of the most troublesome comorbidities among hemodialysis patients (HD). Myostatin (MSTN) belongs to the transforming growth factor-β superfamily. In HD patients, MSTN effects are not limited to skeletal muscle growth. The present study aimed to assess MSTN levels in HD patients and its relation to various clinical and biochemical parameters. Patients and methods: The present case control study included 60 patients on HD for at least three years. In addition, there were age and sex-matched healthy subjects who constitutes the control group. Nutritional status was evaluated using the malnutrition inflammation score (MIS). Muscle wasting in the present study was evaluated using the lean tissue index (LTI) as assessed by the body composition monitor (BCM). Rectus Femoris Muscle (RFM) thickness was also measured as indicator for nutritional status of patient. Results: The present study included 60 HD patients, and ageand sex-matched healthy controls. Patients expressed significantly higher myostatin levels when compared to controls [median (IQR): 221.3 (153.5-688.2) versus 144.8 (97.0-281.7), p < 0.001]. According to MIS, patients were classified into those with no/mild malnutrition (n = 22) and others with moderate/severe malnutrition (n = 38). Comparison between the two subgroups revealed that the former group had significantly lower myostatin levels [167.7 (150.3-236.3) versus 341.7 (160.9-955.9), p = 0.004]. According to LTI, patients were classified into those with muscle wasting (n = 23) and others without muscle wasting (n = 37). Comparative analysis showed that patients in the former group had significantly higher myostatin levels [775.1 (325.1-2133.7) versus 161.8 (142.6-302.3), p < 0.001]. Conclusions: Myostatin seems to be a promising marker for identification of malnutrition and muscle wasting in HD patients. https://www.pagepressjournals.org/index.php/aiua/article/view/11869Hemodialysismalnutritionmuscle wastingmyostatin |
| spellingShingle | Amal H. Ibrahim Sammar A. Kasim Alshimaa A. Ezzat Noha E. Ibrahim Donia A. Hassan Amira Sh. Ibrahim Tamer A. Abouelgreed Ehab M. Abdo Naglaa M. Aboelsoud Nermeen M. Abdelmonem Mohammad Thabet Alnajem Ahmed A. Aboomar Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients Archivio Italiano di Urologia e Andrologia Hemodialysis malnutrition muscle wasting myostatin |
| title | Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients |
| title_full | Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients |
| title_fullStr | Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients |
| title_full_unstemmed | Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients |
| title_short | Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients |
| title_sort | relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients |
| topic | Hemodialysis malnutrition muscle wasting myostatin |
| url | https://www.pagepressjournals.org/index.php/aiua/article/view/11869 |
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