Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application
Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles. SLNs were developed to overcome the limitations of other colloidal carriers, such as emulsio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2015-09-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-305.pdf |
| Summary: | Lipid nanoparticles (LNPs) have attracted
special interest during last few decades. Solid lipid nanoparticles (SLNs) and
nanostructured lipid carriers (NLCs) are two major types of Lipid-based
nanoparticles. SLNs were developed to overcome the limitations of other
colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles
because they have advantages like good release profile and targeted drug
delivery with excellent physical stability. In the next generation of the lipid
nanoparticle, NLCs are modified SLNs which improve the stability and capacity
loading. Three structural models of NLCs have been proposed. These LNPs have potential
applications in drug delivery field, research, cosmetics, clinical medicine,
etc. This article focuses on features, structure and innovation of LNPs and
presents a wide discussion about preparation methods, advantages, disadvantages
and applications of LNPs by focusing on SLNs and NLCs. |
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| ISSN: | 2228-5881 2251-7308 |