Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application
Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles. SLNs were developed to overcome the limitations of other colloidal carriers, such as emulsio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2015-09-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-305.pdf |
| _version_ | 1818642712718475264 |
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| author | Neda Naseri Hadi Valizadeh Parvin Zakeri-Milani |
| author_facet | Neda Naseri Hadi Valizadeh Parvin Zakeri-Milani |
| author_sort | Neda Naseri |
| collection | DOAJ |
| description | Lipid nanoparticles (LNPs) have attracted
special interest during last few decades. Solid lipid nanoparticles (SLNs) and
nanostructured lipid carriers (NLCs) are two major types of Lipid-based
nanoparticles. SLNs were developed to overcome the limitations of other
colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles
because they have advantages like good release profile and targeted drug
delivery with excellent physical stability. In the next generation of the lipid
nanoparticle, NLCs are modified SLNs which improve the stability and capacity
loading. Three structural models of NLCs have been proposed. These LNPs have potential
applications in drug delivery field, research, cosmetics, clinical medicine,
etc. This article focuses on features, structure and innovation of LNPs and
presents a wide discussion about preparation methods, advantages, disadvantages
and applications of LNPs by focusing on SLNs and NLCs. |
| first_indexed | 2024-12-16T23:47:25Z |
| format | Article |
| id | doaj.art-094492839dc1409a8ce9555a5e04b888 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-16T23:47:25Z |
| publishDate | 2015-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-094492839dc1409a8ce9555a5e04b8882022-12-21T22:11:27ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082015-09-015330531310.15171/apb.2015.043APB_105_20150515201817Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and ApplicationNeda Naseri0Hadi Valizadeh1Parvin Zakeri-Milani2Student Research Committee and Faculty of Advanced Medical Sciences, Department of Medical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles. SLNs were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good release profile and targeted drug delivery with excellent physical stability. In the next generation of the lipid nanoparticle, NLCs are modified SLNs which improve the stability and capacity loading. Three structural models of NLCs have been proposed. These LNPs have potential applications in drug delivery field, research, cosmetics, clinical medicine, etc. This article focuses on features, structure and innovation of LNPs and presents a wide discussion about preparation methods, advantages, disadvantages and applications of LNPs by focusing on SLNs and NLCs.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-305.pdfColloidal carriersSLNsNLCsphysical stabilitypreparation methods |
| spellingShingle | Neda Naseri Hadi Valizadeh Parvin Zakeri-Milani Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application Advanced Pharmaceutical Bulletin Colloidal carriers SLNs NLCs physical stability preparation methods |
| title | Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure,
Preparation and Application |
| title_full | Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure,
Preparation and Application |
| title_fullStr | Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure,
Preparation and Application |
| title_full_unstemmed | Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure,
Preparation and Application |
| title_short | Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure,
Preparation and Application |
| title_sort | solid lipid nanoparticles and nanostructured lipid carriers structure preparation and application |
| topic | Colloidal carriers SLNs NLCs physical stability preparation methods |
| url | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-305.pdf |
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